Associations between the CNTNAP2 gene, dorsolateral prefrontal cortex, and cognitive performance on the Stroop task.

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Abstract

The CNTNAP2 (contactin-associated protein-like 2) gene, highly expressed in the human prefrontal cortex, has been linked with autism and language impairment. Potential relationships between CNTNAP2, dorsolateral prefrontal cortex (DLPFC), and cognition have been suggested by previous clinical studies, but have not been directly examined in the same study. The current study collected structural MRI, genetic, and behavioral data in 317 healthy Chinese adults, and examined associations between CNTNAP2 variants, DLPFC, and cognitive performance (measured by the Stroop task). After controlling for intracranial volume, sex, and age, the CNTNAP2 genetic polymorphism at SNP rs7809486 had the strongest association with bilateral DLPFC volume (p=0.00015 and 0.00014 for left and right DLPFC volumes, respectively), with GG homozygotes having greater bilateral DLPFC volumes and surface areas than the other genotypes. Furthermore, TT homozygotes of CNTNAP2 rs4726946 (a nearby SNP that had moderate linkage disequilibrium with rs7809486) had greater left DLPFC volume and surface area, and better cognitive performance than the other genotypes. Subjects with greater left DLPFC surface area had better cognitive performance. Importantly, the left DLPFC surface area mediated the association between the CNTNAP2 rs4726946 genotype and cognitive performance. This study provides the first evidence for associations among the CNTNAP2 gene, left DLPFC structure, and cognitive control.

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Author and article information

Journal

Journal ID (iso-abbrev): Neuroscience

Title: Neuroscience

Publisher: Elsevier BV

ISSN (Electronic): 1873-7544

ISSN (Print): 0306-4522

Publication date (Electronic): February 20 2017

Volume: 343

Affiliations

[1 ] State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China; Institute of Developmental Psychology, Beijing Normal University, Beijing, China. Electronic address: zhubi@bnu.edu.cn.

[2 ] Department of Psychology and Social Behavior, University of California, Irvine, CA, USA.

[3 ] State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China.

[4 ] School of Psychology, Beijing Normal University, Beijing, China.

[5 ] Capital Institute of Pediatrics, Beijing, China.

[6 ] Institute of Automation, Chinese Academy of Sciences, Beijing, China.

[7 ] Department of Biological Chemistry and Institute of Genomics and Bioinformatics, University of California, Irvine, CA, USA.

[8 ] State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University, Beijing, China; Institute of Developmental Psychology, Beijing Normal University, Beijing, China.

Article

Publisher Item ID: S0306-4522(16)30642-X

DOI: 10.1016/j.neuroscience.2016.11.021

PubMed ID: 27916731

SO-VID: e74cd3d2-e67a-4636-bc0c-f486d0c0433e

History

Keywords: MRI,Stroop,dorsolateral prefrontal cortex,gene,imaging genetics

Data availability:

Keywords: MRI, Stroop, dorsolateral prefrontal cortex, gene, imaging genetics

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