Body composition measurement in young children using quantitative magnetic resonance: A comparison with air displacement plethysmography

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Abstract

Background

Quantitative magnetic resonance (QMR) has been increasingly used to measure human body composition, but its use and validation in children is limited.

Objective

We compared body composition measurement by QMR and air displacement plethysmography (ADP) in preschool children from Singapore’s multi-ethnic Asian population [ n= 152; mean ± SD age: 5.0 ± 0.1 years].

Methods

Agreements between QMR- and ADP-based fat mass and fat mass index (FMI) were assessed using intraclass correlation coefficient (ICC), reduced major axis regression (RMAR), and Bland-Altman plot analyses. Analyses were stratified for the child’s sex.

Results

Substantial agreement was observed between QMR- and ADP-based fat mass (ICC: 0.85) and FMI (ICC: 0.82). RMAR analysis suggested that QMR measurements were generally lower than ADP measurements. Bland-Altman analysis similarly revealed that QMR-based fat mass were [mean difference (95% limits of agreement)] -0.5 (-2.1 to +1.1) kg lower than ADP-based fat mass and QMR-based FMI were -0.4 (-1.8 to +0.9) kg/m ² lower than ADP-based FMI. Stratification by offspring sex revealed better agreement of QMR and ADP measurements in girls than in boys.

Conclusions

QMR-based fat mass and FMI showed substantial agreement with, but was generally lower than, ADP-based measures in young Asian children.

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Author and article information

Journal

Journal ID (nlm-journal-id): 101572033

Journal ID (pubmed-jr-id): 39636

Journal ID (nlm-ta): Pediatr Obes

Journal ID (iso-abbrev): Pediatr Obes

Title: Pediatric obesity

ISSN (Print): 2047-6302

ISSN (Electronic): 2047-6310

Publication date Nihms-submitted: 1 November 2017

Publication date (Electronic): 12 October 2017

Publication date (Print): June 2018

Publication date PMC-release: 01 December 2018

Volume: 13

Issue: 6

Pages: 365-373

Affiliations

[1 ]Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

[2 ]Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

[3 ]Department of Diagnostic and Interventional Imaging, KK Women’s and Children’s Hospital, Singapore

[4 ]Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore

[5 ]Department of Maternal Fetal Medicine, KK Women’s and Children’s Hospital, Singapore

[6 ]Duke-National University of Singapore Graduate Medical School, Singapore

[7 ]Department of Neonatology, KK Women’s and Children’s Hospital, Singapore

[8 ]Liggins Institute, University of Auckland, New Zealand

[9 ]MRC Lifecourse Epidemiology Unit & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, UK

[10 ]Departments of Pediatrics and of Epidemiology, Biostatistics and Occupational Health, McGill University Faculty of Medicine, Canada

[11 ]Clinical Nutrition Research Centre, Singapore Institute for Clinical Sciences, A*STAR, Singapore

[12 ]Department of Pediatric Endocrinology, KK Women’s and Children’s Hospital, Singapore

[13 ]Khoo Teck Puat- National University Children’s Medical Institute, National University Health System, Singapore

Author notes

[* ] Address correspondence and requests for reprints to: Yung Seng Lee (to whom the proofs should be sent), Department of Paediatrics, Yong Loo Lin School of Medicine, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore 119228; Phone: (65) 67724420; Fax: (65) 67797486; paeleeys@ 123456nus.edu.sg ; Fabian Yap, Department of Paediatrics, KK Women’s and Children’s Hospital, Singapore Children’s Tower Level 3, 100 Bukit Timah Road, S229899; Phone: (65) 6394 8841 Fax: (65) 6394 1700; fabian.yap.k.p@ 123456singhealth.com.sg

Article

Accession ID: PMC5805128 Pmcid ID: PMC5805128 Pmc-uid ID: 5805128 Manuscript ID: ems74739

DOI: 10.1111/ijpo.12250

PMC ID: 5805128

PubMed ID: 29024557

SO-VID: e6a65d00-7618-4ec6-aa07-45d05b5f300b

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