Probable and possible transfusion-transmitted dengue associated with NS1 antigen-negative but RNA confirmed-positive red blood cells.

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Abstract

In the absence of active blood donation screening, dengue viruses (DENV) have been implicated in only a limited number of transfusion transmissions worldwide. This study attempted to identify if blood from donors testing negative by an NS1-antigen (Ag) enzyme-linked immunosorbent assay (ELISA) but confirmed positive for DENV RNA caused DENV-related disease in recipients during the epidemic years of 2010 to 2012 in Puerto Rico.

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Journal

Journal ID (iso-abbrev): Transfusion

Title: Transfusion

Publisher: Wiley-Blackwell

ISSN (Electronic): 1537-2995

ISSN (Print): 0041-1132

Publication date (Electronic): Jan 2016

Volume: 56

Issue: 1

Affiliations

[1 ] American Red Cross Blood Services Region and.

[2 ] Dengue Branch, Centers for Disease Control and Prevention, San Juan, Puerto Rico.

[3 ] Division of Vector-Borne Disease Information Technology Support, Centers for Disease Control and Prevention, Fort Collins, Colorado.

[4 ] American Red Cross Scientific Support Office, Gaithersburg, Maryland.

[5 ] Blood Systems Research Institute, San Francisco, California.

[6 ] Hologic, San Diego, California.

Article

DOI: 10.1111/trf.13288

PubMed ID: 26469514

SO-VID: e680b7f6-c1e8-43e2-827c-cf14d698613b

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