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      Appetite control

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          Abstract

          Our understanding of the physiological systems that regulate food intake and body weight has increased immensely over the past decade. Brain centres, including the hypothalamus, brainstem and reward centres, signal via neuropeptides which regulate energy homeostasis. Insulin and hormones synthesized by adipose tissue reflect the long-term nutritional status of the body and are able to influence these circuits. Circulating gut hormones modulate these pathways acutely and result in appetite stimulation or satiety effects. This review discusses central neuronal networks and peripheral signals which contribute energy homeostasis, and how a loss of the homeostatic process may result in obesity. It also considers future therapeutic targets for the treatment of obesity.

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          Author and article information

          Journal
          Journal of Endocrinology
          Society for Endocrinology
          0022-0795
          1479-6805
          February 2005
          February 2005
          : 184
          : 2
          : 291-318
          Article
          10.1677/joe.1.05866
          15684339
          e6591fef-8f82-4584-a9db-87a84c24753c
          © 2005

          Free to read

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