Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling.

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Abstract

Patients with irritable bowel syndrome (IBS) have increased activity in the insula and reduced activation of the dorsolateral prefrontal cortex (DLPFC) in response to visceral stimulation. We investigated whether they have latent impairments in cognitive flexibility because of dysfunction in the DLPFC and insula and altered connectivity between brain regions.

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Journal

Journal ID (iso-abbrev): Gastroenterology

Title: Gastroenterology

Publisher: Elsevier BV

ISSN (Electronic): 1528-0012

ISSN (Print): 0016-5085

Publication date (Electronic): Nov 2012

Volume: 143

Issue: 5

Affiliations

[1 ] Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.

[2 ] Department of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan.

[3 ] Primate Research Institute, Kyoto University, Kyoto, Japan.

[4 ] Department of Clinical Neuroscience, Yamagata University Graduate School of Medicine, Yamagata, Japan.

[5 ] Sendai Nakae Hospital, Sendai, Japan.

[6 ] Department of Physiology, Tohoku University Graduate School of Medicine, Sendai, Japan.

[7 ] Department of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan; Department of Comprehensive Medicine, Tohoku University Hospital, Sendai, Japan.

[8 ] Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Department of Psychosomatic Medicine, Tohoku University Hospital, Sendai, Japan. Electronic address: sfukudo@med.tohoku.ac.jp.

Article

Publisher Item ID: S0016-5085(12)01129-8

DOI: 10.1053/j.gastro.2012.07.104

PubMed ID: 22841782

SO-VID: e61b6e29-5b41-4fab-8f80-a9b4b4b90786

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