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      Patient- and 3D morphometry-based nose outcomes after skeletofacial reconstruction

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          Abstract

          Patient satisfaction with the shape and appearance of their nose after orthognathic surgery-based skeletofacial reconstruction is an important, but often overlooked, outcome. We assessed the nose-related outcomes through a recently developed patient-reported outcome instrument and a widely adopted 3D computer-based objective outcome instrument, to verify any correlation in the results produced by these tools. We collected FACE-Q nose appearance reports (2 scales) and 3D nasal morphometry (10 parameters) from patients with class III skeletal pattern and congenital cleft lip palate deformity (n = 23) or developmental dentofacial deformity (n = 23) after (>12 months) skeletofacial reconstruction. The cleft and dentofacial cohorts demonstrated significantly (p < 0.001) poorer satisfaction scores with regard to the FACE-Q nostrils scale than the normal age-, gender-, and ethnicity-matched subjects (n = 107), without any significant difference in FACE-Q nose scale. The cleft cohort had significantly (p < 0.001) smaller nasal length, nasal tip projection, and columellar angle and greater nasal protrusion, alar width, and columellar–labial angle values than the dentofacial and normal cohorts; however, there were no significant differences between the dentofacial versus normal cohorts. The FACE-Q nose and nostrils scales were significantly (p < 0.001; r = −0.26–0.27) correlated to the results of the 3D morphometric analysis, with regard to nasal length, alar width, columella angle, and columellar–labial angle parameters. This study revealed differences in satisfaction with the appearance of the nose according to the type of underlying deformity, and demonstrated a significant correlation (low correlation coefficients) between the patient-reports and 3D image-based outcome measure tools, which has implications for multidisciplinary-centered research, auditing, and clinical care.

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          Maximising the impact of patient reported outcome assessment for patients and society

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            New growth charts for Taiwanese children and adolescents based on World Health Organization standards and health-related physical fitness.

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              Making the best match: selecting outcome measures for clinical trials and outcome studies.

              Selecting an appropriate outcome measure is a critical step in designing valid and useful clinical trials and outcome studies. This selection process needs to extend beyond examining basic psychometric properties to consider additional features of instruments that may affect their validity and utility for the study's purpose. This article discusses these additional factors and their potential impact on outcome measurement. Guidelines are proposed to help clinical researchers and consumers of clinical research literature evaluate the match between the study purpose, population, and instrument.
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                Author and article information

                Contributors
                lunjoulo@cgmh.org.tw
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                6 March 2020
                6 March 2020
                2020
                : 10
                : 4246
                Affiliations
                [1 ]GRID grid.145695.a, Department of Plastic and Reconstructive Surgery and Craniofacial Research Center, Chang Gung Memorial Hospital, , Chang Gung University, ; Taoyuan, Taiwan
                [2 ]ISNI 0000 0000 8611 7824, GRID grid.412588.2, Department of Plastic and Reconstructive Surgery, , Pusan National University Hospital, ; Busan, Korea
                [3 ]ISNI 0000 0001 2190 5763, GRID grid.7727.5, Centre of Plastic, Aesthetic, Hand and Reconstructive Surgery, , University of Regensburg, Franz-Josef-Strauß-Allee, ; Regensburg, Germany
                [4 ]Department of Plastic and Reconstructive Surgery, Helios Hospital München West, Munich, Germany
                [5 ]ISNI 0000 0001 0711 0593, GRID grid.413801.f, Image Lab and Craniofacial Research Center, , Chang Gung Memorial Hospital, ; Taoyuan, Taiwan
                [6 ]ISNI 0000 0001 0711 0593, GRID grid.413801.f, Department of Craniofacial Orthodontics and Craniofacial Research Center, , Chang Gung Memorial Hospital, ; Taoyuan, Taiwan
                Author information
                http://orcid.org/0000-0003-0525-3480
                Article
                61233
                10.1038/s41598-020-61233-6
                7060327
                32144392
                e5c849c8-760b-4e37-a5f3-ead40a91293f
                © The Author(s) 2020

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 15 August 2019
                : 18 February 2020
                Funding
                Funded by: FundRef https://doi.org/10.13039/501100004663, Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan);
                Award ID: MOST 106−2314−B−182−027−MY2
                Award Recipient :
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                © The Author(s) 2020

                Uncategorized
                three-dimensional imaging,outcomes research
                Uncategorized
                three-dimensional imaging, outcomes research

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