Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases.

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Abstract

Phosphatidylinositol 3'-kinase (PI3-kinase) is implicated in cell migration and focal adhesion kinase (FAK) phosphorylation. In contrast, it has been proposed that mitogen-activated protein (MAP) kinases are essential for proliferation but may be dissociated from chemotactic signalling. We investigated the roles of PI3-kinase and p42/p44 MAP kinases in cell migration and FAK tyrosine phosphorylation induced by platelet-derived growth factor-BB (PDGF-BB) in rabbit aortic vascular smooth muscle cells (VSMCs). The roles of PI3-kinase and MAP kinase pathways in the chemotactic response to insulin-like growth factor-I (IGF-I) were also examined.

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Journal

Journal ID (iso-abbrev): Cardiovasc. Res.

Title: Cardiovascular research

ISSN: 0008-6363

ISSN (Print): 0008-6363

Publication date (Electronic): Mar 1999

Volume: 41

Issue: 3

Affiliations

[1 ] Wolfson Institute for Biomedical Research, University College London, UK.

Article

Publisher Item ID: S0008-6363(98)00232-6

PubMed ID: 10435043

SO-VID: e55c6433-c3e0-46a4-9ebf-2fd4c3816f6b

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