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Immune modulating effects of receptor interacting protein 2 (RIP2) in autoinflammation and immunity
February 2021
February 2021
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Abstract
Receptor-interacting protein 2 (RIP2) is a kinase that is involved in downstream signaling
of nuclear oligomerization domain (NOD)-like receptors NOD1 and 2 sensing bacterial
peptidoglycans. RIP2-deficiency or targeting of RIP2 by pharmaceutical inhibitors
partially ameliorates inflammatory diseases by reducing pro-inflammatory signaling
in response to peptidoglycans. However, RIP2 is widely expressed and interacts with
several other proteins suggesting additional functions outside the NOD-signaling pathway.
In this review, we discuss the immunological functions of RIP2 and its possible role
in autoinflammation and immunity.
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