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      Treatment strategies for insomnia in Japanese primary care physicians’ practice: A Web-based questionnaire survey

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          Abstract

          Background

          It is unclear how primary care physicians manage insomnia after the introduction of novel hypnotics such as orexin receptor antagonists and melatonin receptor agonists. This Web-based questionnaire survey aimed to examine treatment strategies for insomnia in Japanese primary care practice.

          Methods

          One-hundred-and-seventeen primary care physicians were surveyed on the familiarity of each management option for insomnia on a binary response scale (0 = “unfamiliar”; 1 = “familiar”) and how they managed insomnia using a nine-point Likert scale (1 = “I never prescribe/perform it”; 9 = “I often prescribe/perform it”). Physicians who were unfamiliar with a management option were deemed to have never prescribed or performed it.

          Results

          Regarding medication, most physicians were familiar with novel hypnotics. Suvorexant was the most used hypnotic, followed by lemborexant and ramelteon. These novel hypnotics averaged 4.8–5.4 points and 4.0–4.7 points for sleep onset and sleep maintenance insomnia, respectively. By contrast, most benzodiazepines were seldom used below two points. Regarding psychotherapy, only approximately 40% of the physicians were familiar with cognitive behavioral therapy for insomnia (CBT-I) and they rarely implemented it, at an average of 1.5–1.6 points. More physicians were familiar with single-component psychotherapies (i.e., relaxation, sleep restriction therapy, and stimulus control) compared to CBT-I, and 48–74% of them implemented it slightly more often, with scores ranging from 2.6 to 3.4 points.

          Conclusion

          This study suggests that Japanese primary care physicians seldom use CBT-I to treat insomnia. In addition, they use novel sleep medications more frequently than benzodiazepines in terms of pharmacotherapy. The use and availability of CBT-I in Japanese primary care might be facilitated by: educating primary care physicians, implementing brief or digital CBT-I, and/or developing collaborations between primary care physicians and CBT-I specialists.

          Supplementary Information

          The online version contains supplementary material available at 10.1186/s12875-024-02449-7.

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          Most cited references29

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          European guideline for the diagnosis and treatment of insomnia

          This European guideline for the diagnosis and treatment of insomnia was developed by a task force of the European Sleep Research Society, with the aim of providing clinical recommendations for the management of adult patients with insomnia. The guideline is based on a systematic review of relevant meta-analyses published till June 2016. The target audience for this guideline includes all clinicians involved in the management of insomnia, and the target patient population includes adults with chronic insomnia disorder. The GRADE (Grading of Recommendations Assessment, Development and Evaluation) system was used to grade the evidence and guide recommendations. The diagnostic procedure for insomnia, and its co-morbidities, should include a clinical interview consisting of a sleep history (sleep habits, sleep environment, work schedules, circadian factors), the use of sleep questionnaires and sleep diaries, questions about somatic and mental health, a physical examination and additional measures if indicated (i.e. blood tests, electrocardiogram, electroencephalogram; strong recommendation, moderate- to high-quality evidence). Polysomnography can be used to evaluate other sleep disorders if suspected (i.e. periodic limb movement disorder, sleep-related breathing disorders), in treatment-resistant insomnia, for professional at-risk populations and when substantial sleep state misperception is suspected (strong recommendation, high-quality evidence). Cognitive behavioural therapy for insomnia is recommended as the first-line treatment for chronic insomnia in adults of any age (strong recommendation, high-quality evidence). A pharmacological intervention can be offered if cognitive behavioural therapy for insomnia is not sufficiently effective or not available. Benzodiazepines, benzodiazepine receptor agonists and some antidepressants are effective in the short-term treatment of insomnia (≤4 weeks; weak recommendation, moderate-quality evidence). Antihistamines, antipsychotics, melatonin and phytotherapeutics are not recommended for insomnia treatment (strong to weak recommendations, low- to very-low-quality evidence). Light therapy and exercise need to be further evaluated to judge their usefulness in the treatment of insomnia (weak recommendation, low-quality evidence). Complementary and alternative treatments (e.g. homeopathy, acupuncture) are not recommended for insomnia treatment (weak recommendation, very-low-quality evidence).
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            Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline.

            The purpose of this guideline is to establish clinical practice recommendations for the pharmacologic treatment of chronic insomnia in adults, when such treatment is clinically indicated. Unlike previous meta-analyses, which focused on broad classes of drugs, this guideline focuses on individual drugs commonly used to treat insomnia. It includes drugs that are FDA-approved for the treatment of insomnia, as well as several drugs commonly used to treat insomnia without an FDA indication for this condition. This guideline should be used in conjunction with other AASM guidelines on the evaluation and treatment of chronic insomnia in adults.
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              Meta-analysis of the impact of 9 medication classes on falls in elderly persons.

              There is increasing recognition that the use of certain medications contributes to falls in seniors. Our objective was to update a previously completed meta-analysis looking at the association of medication use and falling to include relevant drug classes and new studies that have been completed since a previous meta-analysis. Studies were identified through a systematic search of English-language articles published from 1996 to 2007. We identified studies that were completed on patients older than 60 years, looking at the association between medication use and falling. Bayesian methods allowed us to combine the results of a previous meta-analysis with new information to estimate updated Bayesian odds ratios (ORs) and 95% credible intervals (95% CrIs) Of 11 118 identified articles, 22 met our inclusion criteria. Meta-analyses were completed on 9 unique drug classes, including 79 081 participants, with the following Bayesian unadjusted OR estimates: antihypertensive agents, OR, 1.24 (95% CrI, 1.01-1.50); diuretics, OR, 1.07 (95% CrI, 1.01-1.14); beta-blockers, OR, 1.01 (95% CrI, 0.86-1.17); sedatives and hypnotics, OR, 1.47 (95% CrI, 1.35-1.62); neuroleptics and antipsychotics, OR, 1.59 (95% CrI, 1.37-1.83); antidepressants, OR, 1.68 (95% CrI, 1.47-1.91); benzodiazepines, OR, 1.57 (95% CrI, 1.43-1.72); narcotics, OR, 0.96 (95% CrI, 0.78-1.18); and nonsteroidal anti-inflammatory drugs, OR, 1.21 (95% CrI, 1.01-1.44). The updated Bayesian adjusted OR estimates for diuretics, neuroleptics and antipsychotics, antidepressants, and benzodiazepines were 0.99 (95% CrI, 0.78-1.25), 1.39 (95% CrI, 0.94-2.00), 1.36 (95% CrI, 1.13-1.76), and 1.41 (95% CrI, 1.20-1.71), respectively. Stratification of studies had little effect on Bayesian OR estimates, with only small differences in the stratified ORs observed across population (for beta-blockers and neuroleptics and antipsychotics) and study type (for sedatives and hypnotics, benzodiazepines, and narcotics). An increased likelihood of falling was estimated for the use of sedatives and hypnotics, neuroleptics and antipsychotics, antidepressants, benzodiazepines, and nonsteroidal anti-inflammatory drugs in studies considered to have "good" medication and falls ascertainment. The use of sedatives and hypnotics, antidepressants, and benzodiazepines demonstrated a significant association with falls in elderly individuals.
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                Author and article information

                Contributors
                takaesuy@med.u-ryukyu.ac.jp
                Journal
                BMC Prim Care
                BMC Prim Care
                BMC Primary Care
                BioMed Central (London )
                2731-4553
                18 June 2024
                18 June 2024
                2024
                : 25
                : 219
                Affiliations
                [1 ]Department of Neuropsychiatry, Akita University Graduate School of Medicine, ( https://ror.org/03hv1ad10) Akita City, Japan
                [2 ]Department of Neuropsychiatry, Kyorin University Faculty of Medicine, ( https://ror.org/0188yz413) Tokyo, Japan
                [3 ]Department of Psychiatry, Kitasato University School of Medicine, ( https://ror.org/00f2txz25) Sagamihara City, Japan
                [4 ]Psychiatric and Mental Health Nursing, Graduate School of Nursing Science, St. Luke’s International University, ( https://ror.org/00e5yzw53) Tokyo, Japan
                [5 ]Department of General Internal Medicine, St. Marianna University School of Medicine, ( https://ror.org/043axf581) Kawasaki City, Japan
                [6 ]Department of General Internal Medicine, Kawasaki Municipal Tama Hospital, ( https://ror.org/025bm0k33) Kawasaki City, Japan
                [7 ]Centre for Family Medicine Development, Japanese Health and Welfare Co-Operative Federation, Tokyo, Japan
                [8 ]Department of General Internal Medicine, Kawasaki Kyodo Hospital, Kawasaki Health Cooperative Association, Kawasaki City, Japan
                [9 ]Department of Clinical Laboratory, National Center of Neurology and Psychiatry, National Center Hospital, ( https://ror.org/0254bmq54) Tokyo, Japan
                [10 ]GRID grid.416859.7, ISNI 0000 0000 9832 2227, Department of Sleep-Wake Disorders, National Center of Neurology and Psychiatry, , National Institute of Mental Health, ; Tokyo, Japan
                [11 ]Department of Psychiatry, The Jikei University School of Medicine, ( https://ror.org/039ygjf22) Tokyo, Japan
                [12 ]Department of Psychiatry, Tokyo Medical University, ( https://ror.org/00k5j5c86) Tokyo, Japan
                [13 ]Department of Psychological Counseling, Faculty of Humanities, Tokyo Kasei University, ( https://ror.org/05xbyzq55) Tokyo, Japan
                [14 ]Kotorii Isahaya Hospital, Isahaya City, Japan
                [15 ]Minnano Sleep and Stress Care Clinic, Hiroshima City, Japan
                [16 ]Department of Psychiatry, Nihon University School of Medicine, ( https://ror.org/05jk51a88) Tokyo, Japan
                [17 ]Department of Psychiatry, National Center of Neurology and Psychiatry, National Center Hospital, ( https://ror.org/0254bmq54) Tokyo, Japan
                [18 ]Research Center for Child Mental Development, Chiba University, ( https://ror.org/01hjzeq58) Chiba City, Japan
                [19 ]Department of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine, ( https://ror.org/01hjzeq58) Chiba City, Japan
                [20 ]Department of Neuropsychiatry, Graduate School of Medicine, University of the Ryukyus, ( https://ror.org/02z1n9q24) Nishihara-cho, Japan
                Article
                2449
                10.1186/s12875-024-02449-7
                11184713
                38890610
                e3889420-89c9-44cc-83f1-8dbf1830f786
                © The Author(s) 2024

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 27 May 2023
                : 24 May 2024
                Funding
                Funded by: The Ministry of Health, Labor and Welfare of Japan
                Award ID: 21GC1016
                Award Recipient :
                Categories
                Research
                Custom metadata
                © BioMed Central Ltd., part of Springer Nature 2024

                benzodiazepine,cognitive behavioral therapy for insomnia,hypnotic; insomnia,primary care

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