Whole-genome sequencing confirms a persistent candidaemia clonal outbreak due to multidrug-resistant Candida parapsilosis.

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Abstract

Although perceived as a rare clinical entity, recent studies have noted the emergence of MDR C. parapsilosis (MDR-Cp) isolates from single patients (resistant to both azole and echinocandins). We previously reported a case series of MDR-Cp isolates carrying a novel FKS1R658G mutation. Herein, we identified an echinocandin-naive patient infected with MDR-Cp a few months after the previously described isolates. WGS and CRISPR-Cas9 editing were used to explore the origin of the new MDR-Cp isolates, and to determine if the novel mutation confers echinocandin resistance.

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Author and article information

Journal

Journal ID (iso-abbrev): J Antimicrob Chemother

Title: The Journal of antimicrobial chemotherapy

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1460-2091

ISSN (Print): 0305-7453

Publication date (Electronic): Jun 01 2023

Volume: 78

Issue: 6

Affiliations

[1 ] Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114USA.

[2 ] Institute of Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam, 1012 WX, The Netherlands.

[3 ] Department of Medical Microbiology, Ege University Faculty of Medicine, Izmir, Turkey.

[4 ] Division of Mycology, Faculty of Medicine, University of Çukurova, Adana, Turkey.

[5 ] Comparative Genomics group, Life Sciences department, Barcelona Supercomputing Center (BSC-CNS), Carrer de Jordi Girona, 29, 31, 08034 Barcelona, Spain.

[6 ] Comparative Genomics group, Mechanisms of Disease Programme, Institute for Research in Biomedicine (IRB), Carrer Baldiri Reixac 10, 08028, Barcelona, Spain.

[7 ] School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin, Ireland.

[8 ] Medical University Innsbruck, Institute of Hygiene and Medical Microbiology, Schöpfstrasse 41, 6020 Innsbruck, Austria.

[9 ] Westerdijk Fungal Biodiversity Institute, Utrecht, 3584CT, The Netherlands.

[10 ] Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, 3584CX, The Netherlands.

[11 ] Department of Medicine, Harvard Medical School, Boston, MA 02115USA.

[12 ] Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, 08010 Barcelona, Spain.

[13 ] Centro de Investigación Biomédica En Red de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain.

Article

Publisher Item ID: 7143692

DOI: 10.1093/jac/dkad112

PMC ID: 10232251

PubMed ID: 37100456

SO-VID: e33b2393-75c5-49c2-86a3-5416cae634a3

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