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      Abdominal Wall Defects—Current Treatments

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Gastroschisis and omphalocele reflect the two most common abdominal wall defects in newborns. First postnatal care consists of defect coverage, avoidance of fluid and heat loss, fluid administration and gastric decompression. Definitive treatment is achieved by defect reduction and abdominal wall closure. Different techniques and timings are used depending on type and size of defect, the abdominal domain and comorbidities of the child. The present review aims to provide an overview of current treatments.

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          Beckwith-Wiedemann syndrome.

          Rosanna Weksberg, Cheryl Shuman, Esteban Beckwith (2009)
          Beckwith-Wiedemann syndrome (BWS) is a model disorder for the study of imprinting, growth dysregulation, and tumorigenesis. Unique observations in this disorder point to an important embryonic developmental window relevant to the observations of increased monozygotic twinning and an increased rate of epigenetic errors after subfertility/assisted reproduction.
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            Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta‐analysis

            L. J. Salomon, A Sotiriadis, C Wulff … (2019)
            Article 0 comments Cited 86 times – based on 0 reviews     Review now
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              Maternal obesity and risk for birth defects.

              Richard Watkins, Wendy Moore, Margaret A. Honein … (2003)
              Several studies have shown an increased risk for neural tube defects associated with prepregnancy maternal obesity. Because few recent studies have examined the relation between maternal prepregnancy obesity and overweight and other birth defects, we explored the relation for several birth defects and compared our findings with those of previous studies. We conducted a population-based case-control study of several selected major birth defects using data from the Atlanta Birth Defects Risk Factor Surveillance Study. Mothers who delivered an infant with and without selected birth defects in a 5-county metropolitan Atlanta area between January 1993 and August 1997 were interviewed. Maternal body mass index (BMI) was calculated from self-reported maternal prepregnancy weight and height. Women with known preexisting diabetes were excluded. The risks for obese women (BMI > or =30) and overweight women (BMI 25.0-29.9) were compared with those for average-weight women (BMI 18.5-24.9). Obese women were more likely than average-weight women to have an infant with spina bifida (unadjusted odds ratio [OR]: 3.5; 95% confidence interval [CI]: 1.2-10.3), omphalocele (OR: 3.3; 95% CI: 1.0-10.3), heart defects (OR: 2.0; 95% CI: 1.2-3.4), and multiple anomalies (OR: 2.0; 95% CI: 1.0-3.8). Overweight women were more likely than average-weight women to have infants with heart defects (OR: 2.0; 95% CI: 1.2-3.1) and multiple anomalies (OR: 1.9; 95% CI: 1.1-3.4). Our study confirmed the previously established association between spina bifida and prepregnancy maternal obesity and found an association for omphalocele, heart defects, and multiple anomalies among infants of obese women. We also found an association between heart defects and multiple anomalies and being overweight before pregnancy. A higher risk for some birth defects is yet another adverse pregnancy outcome associated with maternal obesity. Obesity prevention efforts are needed to increase the number of women who are of healthy weight before pregnancy.
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                Author and article information

                Contributors
                Piotr Kaliciński: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Children (Basel)
                Journal ID (iso-abbrev): Children (Basel)
                Journal ID (publisher-id): children
                Title: Children
                Publisher: MDPI
                ISSN (Electronic): 2227-9067
                Publication date (Electronic): 23 February 2021
                Publication date Collection: February 2021
                Volume: 8
                Issue: 2
                Electronic Location Identifier: 170
                Affiliations
                [1 ]Department of Pediatric Surgery, University Children’s Hospital of Basel (UKBB), 4056 Basel, Switzerland; Isabella.bielicki@ 123456ukbb.ch (I.N.B.); Stefan.holland-cunz@ 123456ukbb.ch (S.G.H.-C.)
                [2 ]Department of Pediatric Surgery, University Children’s Hospital of Colorado, Aurora, CO 80045, USA; stig.somme@ 123456childrenscolorado.org
                [3 ]Section of Pediatric Surgery, Department of General, Visceral and Transplantation Surgery, 69120 Heidelberg, Germany; giovanni_frongia@ 123456gmx.de
                Author notes
                [* ]Correspondence: raphael.vuille-dit-bille@ 123456ukbb.ch ; Tel.: +41-61-704-27-98
                Article
                Publisher ID: children-08-00170
                DOI: 10.3390/children8020170
                PMC ID: 7926339
                PubMed ID: 33672248
                SO-VID: e33aedaa-730d-47a5-abc7-4a27baf5dc14
                Copyright © © 2021 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 23 January 2021
                Date accepted : 15 February 2021
                Categories
                Subject: Review

                Keywords: abdominal wall defect,gastroschisis,omphalocele,treatment
                Data availability:
                Keywords: abdominal wall defect, gastroschisis, omphalocele, treatment

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