For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
12
views
115
references
 Top references
cited by
5
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      273
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Burden of neglected tropical diseases and access to medicine and diagnostics in Ethiopia: a scoping review

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Background

          More than 1.7 billion people are affected by neglected tropical diseases (NTDs) worldwide. Forty percent of the NTD-affected people live in Africa with the poorest, most vulnerable, and hard to reach geographical areas. The NTDs cause significant social and economic burden and deepen marginalization and stigmatization. The World Health Organization’s current roadmap for NTD aims to prevent, control, eliminate, or eradicate 20 tropical diseases. Ethiopia experiences a high burden of these diseases, but current access to diagnostics, medicine, and/or care has been little explored to inform the country’s NTD strategic plan. The overall purpose of the scoping review was to map and characterize the burden of NTDs and challenges in access to diagnostics, medicine, and/or care in Ethiopia.

          Methods

          A systematic search of evidence was conducted in PubMed, Cochrane Library, and Google Scholar from January 2000 until May 2022, without restrictions of language or study design. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review was followed for screening of studies. Key findings were extracted and narrated qualitatively.

          Results

          The search resulted in 4532 articles, of which 105 met the inclusion criteria and were included in the scoping review under three themes: burden of NTDs, access to diagnostics, medicine and/or care, and key barriers. Although gains have been made in the prevention and control of NTDs in Ethiopia, the burden remains high, and progress in access to diagnostics, medicine/drugs, and/or care is very slow. Poverty, poor quality of life, and underfunding of NTD programs decelerate the process of NTD elimination program in the country.

          Conclusions

          The scoping review identified a considerable number of studies on the burden of NTDs in Ethiopia and strategies for diagnosis, treatment, and/or care; however, there is a paucity of evidence on the suitability and potential benefits of novel diagnostic technologies and medicines in the country. A regular review and analysis of such country-level evidence is important to inform the country NTDs roadmap and local implementation strategies.

          Supplementary Information

          The online version contains supplementary material available at 10.1186/s13643-023-02302-5.

          Related collections

          Most cited references115

          • Record: found
          • Abstract: found
          • Article: not found

          PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation

          Adrian Aldcroft, Chantelle Garritty, Simon Lewin … (2018)
          Scoping reviews, a type of knowledge synthesis, follow a systematic approach to map evidence on a topic and identify main concepts, theories, sources, and knowledge gaps. Although more scoping reviews are being done, their methodological and reporting quality need improvement. This document presents the PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) checklist and explanation. The checklist was developed by a 24-member expert panel and 2 research leads following published guidance from the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network. The final checklist contains 20 essential reporting items and 2 optional items. The authors provide a rationale and an example of good reporting for each item. The intent of the PRISMA-ScR is to help readers (including researchers, publishers, commissioners, policymakers, health care providers, guideline developers, and patients or consumers) develop a greater understanding of relevant terminology, core concepts, and key items to report for scoping reviews.
          Article 0 comments Cited 9259 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach

            Zachary Munn, Micah D J Peters, Cindy Stern … (2018)
            Background Scoping reviews are a relatively new approach to evidence synthesis and currently there exists little guidance regarding the decision to choose between a systematic review or scoping review approach when synthesising evidence. The purpose of this article is to clearly describe the differences in indications between scoping reviews and systematic reviews and to provide guidance for when a scoping review is (and is not) appropriate. Results Researchers may conduct scoping reviews instead of systematic reviews where the purpose of the review is to identify knowledge gaps, scope a body of literature, clarify concepts or to investigate research conduct. While useful in their own right, scoping reviews may also be helpful precursors to systematic reviews and can be used to confirm the relevance of inclusion criteria and potential questions. Conclusions Scoping reviews are a useful tool in the ever increasing arsenal of evidence synthesis approaches. Although conducted for different purposes compared to systematic reviews, scoping reviews still require rigorous and transparent methods in their conduct to ensure that the results are trustworthy. Our hope is that with clear guidance available regarding whether to conduct a scoping review or a systematic review, there will be less scoping reviews being performed for inappropriate indications better served by a systematic review, and vice-versa.
            Article 0 comments Cited 2521 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Laboratory evaluation of four HIV/syphilis rapid diagnostic tests

              Annelies Van Den Heuvel, Hilde Smet, Irena Prat … (2019)
              Background Sexually transmitted infections, such as HIV and syphilis, are one of the major health care problems worldwide, especially in low- and middle income countries. HIV screening programmes have been widely used for many years. The introduction of rapid point-of-care tests (RDTs) that can detect both HIV and syphilis, using one single blood specimen, would be a promising tool to integrate the detection of syphilis into HIV programmes and so improve the accessibility of syphilis testing and treatment. Methods As part of the World Health Organization pre-qualification of in vitro diagnostics assessment, the laboratory performance of four dual HIV-Syphilis rapid diagnostic tests (SD Bioline HIV/Syphilis Duo, DPP HIV-Syphilis Assay, Multiplo Rapid TP/HIV Antibody Test and Insti Multiplex HIV-1/HIV-2/Syphilis Antibody Test) was assessed using a well characterized multiregional panel of stored sera specimens. Results In total 400 specimens were tested with each assay, resulting in excellent sensitivities and specificities for HIV, ranging from 99.5 to 100% and from 93.5 to 99.5%, respectively. Results obtained for the Treponema pallidum antibodies were lower, with the lowest sensitivity of 73.5% for Multiplo and the highest of 87% for SD Bioline. Specificities ranged from 99.0 to 100%. Conclusion Although these results suggest that the tests could further improve in accuracy in detection of treponemal antibodies, their introduction into screening programmes to increase the accessibility of HIV/Syphilis diagnosis and treatment for difficult to reach populations in the world is promising.
              Article 0 comments Cited 150 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Agumasie Semahegn:
                ORCID: http://orcid.org/0000-0001-6625-8184
                agumas04@gmail.com
                Tsegahun Manyazewal: tsegahunm@gmail.com
                Eyerusalem Getachew: jerrydebo.eg@gmail.com
                Bethelhem Fekadu: bettyfek2010@gmail.com
                Esubalew Assefa: esubalew.ayalew@gmail.com
                Munir Kassa: munir.kassa@moh.gov.et
                Gail Davey: G.Davey@bsms.ac.uk
                Michael Hopkins: m.m.hopkins@sussex.ac.uk
                Mesele Araya: mesele.arraya@gmail.com
                Tassew Woldehanna: tassew.woldehanna@aau.edu.et
                Charlotte Hanlon: Charlotte.hanlon@kcl.ac.uk
                Abebaw Fekadu: abebaw.fekadu@aau.edu.et
                Journal
                Journal ID (nlm-ta): Syst Rev
                Journal ID (iso-abbrev): Syst Rev
                Title: Systematic Reviews
                Publisher: BioMed Central (London )
                ISSN (Electronic): 2046-4053
                Publication date (Electronic): 14 August 2023
                Publication date PMC-release: 14 August 2023
                Publication date Collection: 2023
                Volume: 12
                Electronic Location Identifier: 140
                Affiliations
                [1 ]GRID grid.7123.7, ISNI 0000 0001 1250 5688, Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), College of Health Sciences, , Addis Ababa University, ; Addis Ababa, Ethiopia
                [2 ]GRID grid.192267.9, ISNI 0000 0001 0108 7468, College of Health and Medical Sciences, , Haramaya University, ; Harar, Ethiopia
                [3 ]Department of Population, Family and Reproductive Health, School of Public Health, Unversity of Ghana, Accra, Ghana
                [4 ]GRID grid.4868.2, ISNI 0000 0001 2171 1133, Health Economics and Policy Research Unit, Wolfson Institute of Population Health, , Queen Mary University of London, ; London, UK
                [5 ]GRID grid.10837.3d, ISNI 0000 0000 9606 9301, Department of Economics, Faculty of Arts and Social Sciences, , The Open University, ; Milton Keynes, UK
                [6 ]GRID grid.414835.f, ISNI 0000 0004 0439 6364, Ministry of Health of Ethiopia, ; Addis Ababa, Ethiopia
                [7 ]GRID grid.414601.6, ISNI 0000 0000 8853 076X, Global Health & Infection Department, Brighton and Sussex Medical School, ; Brighton, UK
                [8 ]GRID grid.7123.7, ISNI 0000 0001 1250 5688, School of Public Health, College of Health Science, , Addis Ababa University, ; Addis Ababa, Ethiopia
                [9 ]GRID grid.12082.39, ISNI 0000 0004 1936 7590, Science Policy Research Unit, , University of Sussex, ; Brighton, UK
                [10 ]GRID grid.7123.7, ISNI 0000 0001 1250 5688, College of Business and Economics, , Addis Ababa University, ; Addis Ababa, Ethiopia
                [11 ]Policy Studies Institute, Addis Ababa, Ethiopia
                [12 ]GRID grid.13097.3c, ISNI 0000 0001 2322 6764, Centre for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, , King’s College London, ; London, UK
                [13 ]GRID grid.7123.7, ISNI 0000 0001 1250 5688, Department of Psychiatry, WHO Collaborating Centre for Mental Health Research and Capacity Building, School of Medicine, College of Health Sciences, , Addis Ababa University, ; Addis Ababa, Ethiopia
                Author information
                http://orcid.org/0000-0001-6625-8184
                Article
                Publisher ID: 2302
                DOI: 10.1186/s13643-023-02302-5
                PMC ID: 10424375
                PubMed ID: 37580784
                SO-VID: e2fb183b-6f23-43bf-b67b-dc0fe338bbf4
                Copyright © © BioMed Central Ltd., part of Springer Nature 2023
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                Date received : 11 October 2022
                Date accepted : 28 July 2023
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/100010269, Wellcome Trust;
                Award ID: Grant ID 221576/Z/20/Z
                Award Recipient :
                Categories
                Subject: Research
                Custom metadata
                issue-copyright-statement © BioMed Central Ltd., part of Springer Nature 2023

                ScienceOpen disciplines: Public health
                Keywords: neglected tropical diseases,diagnosis,treatment,medicine,scoping review,ethiopia
                Data availability:
                ScienceOpen disciplines: Public health
                Keywords: neglected tropical diseases, diagnosis, treatment, medicine, scoping review, ethiopia

                Comments

                Comment on this article

                scite_

                Similar content273

                See all similar

                Cited by5

                See all cited by

                Most referenced authors4,230

                See all reference authors