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      Metabolism in pluripotency: Both driver and passenger?

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          Abstract

          Pluripotent stem cells (PSCs) are highly proliferative cells characterized by robust metabolic demands to power rapid division. For many years considered a passive component or “passenger” of cell-fate determination, cell metabolism is now starting to take center stage as a driver of cell fate outcomes. This review provides an update and analysis of our current understanding of PSC metabolism and its role in self-renewal, differentiation, and somatic cell reprogramming to pluripotency. Moreover, we present evidence on the active roles metabolism plays in shaping the epigenome to influence patterns of gene expression that may model key features of early embryonic development.

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          Author and article information

          Journal
          J Biol Chem
          J. Biol. Chem
          jbc
          jbc
          JBC
          The Journal of Biological Chemistry
          American Society for Biochemistry and Molecular Biology (11200 Rockville Pike, Suite 302, Rockville, MD 20852-3110, U.S.A. )
          0021-9258
          1083-351X
          5 April 2019
          20 February 2018
          20 February 2018
          : 294
          : 14
          : 5420-5429
          Affiliations
          From the Departments of []Pathology and Laboratory Medicine and
          [§ ]Molecular and Medical Pharmacology and
          [§§ ]Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, UCLA, Los Angeles, California 90095,
          the []Department of Biology, California State University at Northridge, Northridge, California 91330,
          the []California NanoSystems Institute,
          [** ]Department of Bioengineering, and
          [‡‡ ]Molecular Biology Institute, UCLA, Los Angeles, California 90095, and
          the [¶¶ ]Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, UCLA, Los Angeles, California 90095
          Author notes
          [1 ] To whom correspondence should be addressed. E-mail: mteitell@ 123456mednet.ucla.edu .

          Edited by John M. Denu

          Article
          PMC6462533 PMC6462533 6462533 TM117.000832
          10.1074/jbc.TM117.000832
          6462533
          29463682
          e28f9a87-ab7a-4115-8f2a-928844ffe854
          © 2019 by The American Society for Biochemistry and Molecular Biology, Inc.
          History
          Funding
          Funded by: National Institutes of Health , open-funder-registry 10.13039/100000002;
          Award ID: CA90571
          Award ID: GM073981
          Award ID: CA18589
          Award ID: GM114188
          Funded by: Air Force Office of Scientific Research , open-funder-registry 10.13039/100000181;
          Award ID: FA9550–15-1–0406
          Categories
          JBC Reviews

          cell fate,differentiation,reprogramming,pluripotency,stem cells,mitochondria,metabolism,epigenetics

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