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2,3,4-Trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran, a Novel Antioxidant, fromPenicillium citrinumF5
May 2002
May 2002
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Abstract
Bioassy-directed fractionation of a culture broth of Penicillium citrinum F5 led to
the isolation of a novel antioxidant 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran
(1), together with gentisic acid (2), and their structures were determined on the
basis of spectroscopic data. In the 1,1-diphenyl-picryl-hydrazyl (DPPH) assay system,
compounds 1 and 2 showed free radical scavenging activity with IC(20) values of 10.39
and 4.26 microM, respectively.