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      A case of exaggerated placental site treated with hysteroscopy

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          Abstract

          Exaggerated placental site (EPS) is a benign lesion that can occur in association with term pregnancy, ectopic pregnancy, molar pregnancy, intrauterine fetal death or miscarriage. The characteristics of EPS are described in several case reports and have been reported after major surgery such as hysterectomy. We describe the hysteroscopic characteristic of EPS associated with a spontaneous miscarriage. Hysteroscopic inspection of the uterine cavity revealed copious tissue with increased vascularization without signs of invasion. No cleavage was visualized between material and myometrium could be established during the resection procedure. 40 days after hysteroscopy the patient became pregnant. The pregnancy proceeded without complications and during the cesarean section no residual placenta-related abnormal site appearance was noted on inspection of the uterine wall. The hysteroscopic treatment could be considered feasible to preserve future fertility in young women in cases of suspect non-malignant trophoblastic disease.

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          Exaggerated placental site, consisting of implantation site intermediate trophoblasts, causes massive postpartum uterine hemorrhage: case report and literature review.

          Every year, 14 million cases of obstetric hemorrhage occur worldwide, causing 127,000 maternal deaths. About 75% of postpartum hemorrhage cases are due to atonic uterus, which is loss of uterine muscular tone or strength for contraction of the uterus after delivery. The prediction of atonic uterus is therefore important for the prevention of postpartum maternal death. However, prediction of occurrence of atonic uterus is difficult before delivery, because the precise pathophysiological mechanism to trigger this condition remains unclear. Here, we present a case of severe postpartum hemorrhage due to atonic uterus. A 35-year-old woman gave a birth by vaginal delivery to a healthy boy. However, due to intractable massive hemorrhage after the removal of the retained placenta, we performed supravaginal hysterectomy as the best option for survival. Pathological examination showed that implantation site intermediate trophoblasts (ISITs) formed unusually large clumps in the decidua, diagnosed as exaggerated placental site (EPS). EPS is thought to be a condition consisting of an excessive number of ISITs. ISITs are differentiated from a trophoblast lineage in the process of placenta formation. ISITs anchor the placenta to the maternal tissue and are considered to maintain pregnancy, but the postpartum role of these cells remains unclear. Excessive infiltration of ISITs, namely EPS, may cause postpartum atonic uterus. In this article, we also reviewed the literatures on EPS. The present case and other reported cases indicate that EPS causes mass formation in the uterus, continuous uterine bleeding, and massive hemorrhage, resulting in hysterectomy.
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            Increased fetal chromosome detection with the use of operative hysteroscopy during evacuation of products of conception for diagnosed miscarriage

            To determine whether incorporation of operative hysteroscopy with biopsy of products of conception, in conjunction with a suction curettage for a first trimester missed abortion, affected the rate of maternal cell contamination when chromosomal analysis was performed on the products of conception, and to determine the rates of retained products of conception with incorporation of hysteroscopy after suction curettage.
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              Exaggerated placental site reaction following an elective abortion.

              We encountered a case of exaggerated placental site (EPS) reaction following an elective abortion. EPS is a miscellaneous trophoblastic lesion. There have been few reports describing its clinical course, and the ultrasonogram and magnetic resonance imaging characteristics have not been reported previously. We present the ultrasonogram and magnetic resonance imaging findings of EPS together with histopathological observations.
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                Author and article information

                Contributors
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                Journal
                AboutOpen
                AboutOpen
                Aboutscience Srl
                2465-2628
                January 11 2024
                January 11 2024
                : 11
                : 1
                : 1-3
                Article
                10.33393/ao.2024.2611
                e1af56c1-c765-46a6-a1b3-e7aa7399d60e
                © 2024

                https://creativecommons.org/licenses/by-nc/4.0

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