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Abstract
Gallbladder cancer (GBC) is an often lethal disease, but surgical resection is potentially
curative. Symptoms may be misdiagnosed as biliary colic; over half of new diagnoses
are made after laparoscopic cholecystectomy for presumed benign disease. Gallbladder
polyps >1 cm should prompt additional imaging and cholecystectomy. For GBC diagnosed
after cholecystectomy, tumors T1b and greater necessitate radical cholecystectomy.
Radical cholecystectomy includes staging laparoscopy, hepatic resection, and locoregional
lymph node clearance to achieve R0 resection. Patients with locally advanced disease
(T3 or T4), hepatic-sided T2 tumors, node positivity, or R1 resection may benefit
from adjuvant chemotherapy. Chemotherapy increases survival in unresectable disease.