Computed tomographic characteristics of gastric schwannoma

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Abstract

Objective

This study aimed to characterize the computed tomographic (CT) features of gastric schwannoma (GS).

Methods

We retrospectively reviewed CT images of 19 cases of histologically proven GS between January 2010 and December 2015. Tumor location, size, contour, margin, growth pattern, and degree and pattern of enhancement, perigastric lymph nodes, ulceration, necrosis, and calcification were evaluated.

Results

GS was located in the gastric body (73.7%), gastric antrum (15.8%), and gastric fundus (10.5%), with a mean maximum diameter of 4.5 ± 1.8 cm. All tumors presented as oval, well-defined solid masses, with exophytic (36.8%), endoluminal (15.8%), or mixed (47.4%) growth patterns. Ulcers (57.9%) and perigastric lymph nodes (47.4%) were observed. Moderate enhancement (87.5%) was observed in the portal phase. Eighteen (94.7%) cases showed homogeneous enhancement.

Conclusions

GS typically presents as a mass in the stomach with an exophytic or mixed growth pattern, moderate homogeneous enhancement, and is prone to be accompanied by perigastric lymph node inflammatory reactive swelling. Larger GSs are more likely to be associated with ulcers.

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Most cited references 29

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Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems.

Andrew L. Folpe, Arie Perry, Caterina Giannini … (2012)

Peripheral nerve sheath tumors are common neoplasms, with classic identifiable features, but on occasion, they are diagnostically challenging. Although well-defined subtypes of peripheral nerve sheath tumors were described early in the history of surgical pathology, controversies regarding the classification and grading of these tumors persist. Advances in molecular biology have provided new insights into the nature of the various peripheral nerve sheath tumors, and have begun to suggest novel targeted therapeutic approaches. In this review, we discuss current concepts and problematic areas in the pathology of peripheral nerve sheath tumors. Diagnostic criteria and differential diagnosis for the major categories of nerve sheath tumors are proposed, including neurofibroma, schwannoma, and perineurioma. Diagnostically challenging variants, including plexiform, cellular and melanotic schwannomas are highlighted. A subset of these affects the childhood population, and has historically been interpreted as malignant, although current evidence and outcome data suggest they represent benign entities. The growing current literature and the author's experience with difficult to classify borderline or "hybrid tumors" are discussed and illustrated. Some of these classification gray zones occur with frequency in the gastrointestinal tract, an anatomical compartment that must always be entertained when examining these neoplasms. Other growing recent areas of interest include the heterogeneous group of pseudoneoplastic lesions involving peripheral nerve composed of mature adipose tissue and/or skeletal muscle, such as the enigmatic neuromuscular choristoma. Malignant peripheral nerve sheath tumors (MPNST) represent a diagnostically controversial group; difficulties in grading and guidelines to separate "atypical neurofibroma" from MPNST are provided. There is an increasing literature of MPNST mimics which neuropathologists must be aware of, including synovial sarcoma and ossifying fibromyxoid tumor. Finally, we discuss entities that are lacking from the section on cranial and paraspinal nerves in the current WHO classification, and that may warrant inclusion in future classifications. In summary, although the diagnosis and classification of most conventional peripheral nerve sheath tumors are relatively straightforward for the experienced observer, yet borderline and difficult-to-classify neoplasms continue to be problematic. In the current review, we attempt to provide some useful guidelines for the surgical neuropathologist to help navigate these persistent, challenging problems.

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Neurogenic tumors in the abdomen: tumor types and imaging characteristics.

Sung Eun Rha, Jae Young Byun, Seung Eun Jung … (2003)

There is a broad spectrum of neurogenic tumors that involve the abdomen. These tumors can be classified as those of (a) ganglion cell origin (ganglioneuromas, ganglioneuroblastomas, neuroblastomas), (b) paraganglionic system origin (pheochromocytomas, paragangliomas), and (c) nerve sheath origin (neurilemmomas, neurofibromas, neurofibromatosis, malignant nerve sheath tumors). Abdominal neurogenic tumors are most commonly located in the retroperitoneum, especially in the paraspinal areas and adrenal glands. All of these tumors except neuroblastomas and ganglioneuroblastomas are seen in adult patients. Abdominal neurogenic tumor commonly manifests radiologically as a well-defined, smooth or lobulated mass. Calcification may be seen in all types of neurogenic tumors. The diagnosis of abdominal neurogenic tumor is suggested by the imaging appearance of the lesion, including its location, shape, and internal architecture. Benign and malignant neurogenic tumors are difficult to differentiate unless distant metastatic foci are seen. For malignant tumors, imaging modalities other than computed tomography (CT) and magnetic resonance (MR) imaging may be necessary for staging. However, because most neurogenic tumors in adults are benign, CT and MR imaging can be used to develop a differential diagnosis and help determine the immediate local extent of tumor. Copyright RSNA, 2003.

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Author and article information

Journal

Journal ID (nlm-ta): J Int Med Res

Journal ID (iso-abbrev): J. Int. Med. Res

Journal ID (publisher-id): IMR

Journal ID (hwp): spimr

Title: The Journal of International Medical Research

Publisher: SAGE Publications (Sage UK: London, England )

ISSN (Print): 0300-0605

ISSN (Electronic): 1473-2300

Publication date (Electronic): 14 March 2019

Publication date (Print): May 2019

Volume: 47

Issue: 5

Pages: 1975-1986

Affiliations

[1 ]Department of Radiology, Fudan University Shanghai Cancer Center (FUSCC), Shanghai, PR China

[2 ]Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China

[3 ]Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, PR China

[4 ]Department of Pathology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, PR China

[5 ]Department of Pathology, Fudan University Shanghai Cancer Center (FUSCC), Shanghai, PR China

Author notes

[*]

These authors contributed equally to this work.

[*]Wei Wang, Fudan University Shanghai Cancer Center (FUSCC), Shanghai Medical College, Fudan University, 270 Dong An Road, Xuhui District, Shanghai, 200032, China. Email: weiwang318@ 123456163.com

Author information

Wei Wang https://orcid.org/0000-0002-2712-6186

Article

Publisher ID: 10.1177_0300060519833539

DOI: 10.1177/0300060519833539

PMC ID: 6567782

PubMed ID: 30871392

SO-VID: e0e35905-b5a7-4260-80e3-843091b269fe

License:

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License ( http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages ( https://us.sagepub.com/en-us/nam/open-access-at-sage).

Computed tomographic characteristics of gastric schwannoma

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Abstract

Objective

Methods

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International Journal of Medicine and Medical Research

Most cited references 29

Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems.

Benign solitary Schwannomas (neurilemomas).

Neurogenic tumors in the abdomen: tumor types and imaging characteristics.

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