Hypoxic modification of radiotherapy in squamous cell carcinoma of the head and neck--a systematic review and meta-analysis.

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Abstract

The importance of tumour hypoxia for the outcome of radiotherapy has been under investigation for decades. Numerous clinical trials modifying the hypoxic radioresistance in squamous cell carcinoma of the head and neck (HNSCC) have been conducted, but most have been inconclusive, partly due to a small number of patients in the individual trial. The present meta-analysis was, therefore, performed utilising the results from all clinical trials addressing the specific question of hypoxic modification in HNSCC undergoing curative intended primary radiotherapy alone.

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Journal

Journal ID (iso-abbrev): Radiother Oncol

Title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Publisher: Elsevier BV

ISSN (Electronic): 1879-0887

ISSN (Print): 0167-8140

Publication date (Electronic): Jul 2011

Volume: 100

Issue: 1

Affiliations

[1 ] Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark. jens@oncology.dk

Article

Publisher Item ID: S0167-8140(11)00125-3

DOI: 10.1016/j.radonc.2011.03.004

PubMed ID: 21511351

SO-VID: e0a88875-78b8-41f9-97fb-f7317df36639

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