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      Different approach, similar outcomes: the impact of surgical access routes in minimally invasive cardiac surgery on enhanced recovery after surgery

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          Abstract

          Objectives

          Enhanced recovery after surgery (ERAS) is a growing phenomenon in all surgical disciplines and aims to achieve a faster functional recovery after major operations. Minimally invasive cardiac surgery (MICS) therefore integrates well into core ERAS values. Surgical access routes in MICS include right anterolateral mini-thoracotomy (MT) as well as partial upper mini-sternotomy (PS). We seek to compare outcomes in these two cohorts, both of which were enrolled in an ERAS scheme.

          Methods

          358 consecutive patients underwent MICS and perioperative ERAS at our institution between 01/2021 and 03/2023. Patients age >80 years, with BMI > 35 kg/m², LVEF ≤ 35%, endocarditis or stroke with residuum were excluded. Retrospective cohort analysis and statistical testing was performed on the remaining 291 patients. The primary endpoint was successful ERAS, secondary endpoints were the occurrence of major bleeding, ERAS-associated complications (reintubation, return to ICU) as well as access-related complications (wound infection, pleural and pericardial effusions).

          Results

          170 (59%) patients received MT for mitral and/or tricuspid valve surgery ( n = 162), closure of atrial septal defect ( n = 4) or resection of left atrial tumor ( n = 4). The remaining 121 (41%) patients had PS for aortic valve repair/replacement ( n = 83) or aortic root/ascending surgery ( n = 22) or both ( n = 16). MT patients’ median age was 63 years (IQR 56–71) and 65% were male, PS patients’ median age was 63 years (IQR 51–69) and 74% were male. 251 (MT 88%, PS 83%, p = 0.73) patients passed through the ERAS program successfully. There were three instances of reintubation (2 MT, 1 PS), and three instances of readmission to ICU (2 MT, 1 PS). Bleeding requiring reexploration occurred six times (3 MT, 3 PS). There was one death (PS), one stroke (MT), and one myocardial infarction requiring revascularization (MT). There were no significant differences in any of the post-operative outcomes recorded, except for the incidence of pericardial effusions (MT 0%, PS 3%, p = 0.03).

          Conclusions

          Despite different surgical access routes and underlying pathologies, results in both the MT and the PS cohort were generally comparable for the recorded outcomes. ERAS remains safe and feasible in these patient groups.

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          Most cited references24

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          Guidelines for Perioperative Care in Cardiac Surgery

          Enhanced Recovery After Surgery (ERAS) evidence-based protocols for perioperative care can lead to improvements in clinical outcomes and cost savings. This article aims to present consensus recommendations for the optimal perioperative management of patients undergoing cardiac surgery. A review of meta-analyses, randomized clinical trials, large nonrandomized studies, and reviews was conducted for each protocol element. The quality of the evidence was graded and used to form consensus recommendations for each topic. Development of these recommendations was endorsed by the Enhanced Recovery After Surgery Society.
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            One-Year Results from the First US-based Enhanced Recovery after Cardiac Surgery (ERAS Cardiac) Program

            Our enhanced recovery after cardiac surgery (ERAS Cardiac) program is an evidence-based interdisciplinary process, which has not previously been systematically applied to cardiac surgery in the United States.
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              Does ministernotomy improve postoperative outcome in aortic valve operation? A prospective randomized study.

              The aim of this study was to compare the postoperative outcome obtained in patients undergoing elective aortic valve operation, either through ministernotomy or conventional sternotomy. Between January 1999 and July 2001, 80 consecutive patients undergoing elective aortic valve replacement were randomly divided into two groups: group I (n = 40 patients) undergoing a ministernotomy approach (reversed-C or reversed-L), and group II (n = 40 patients) undergoing conventional sternotomy. The length of skin incision was significantly shorter in group I than in group II (8.2+/-1.3 cm versus 23.7+/-2.6 cm, p < 0.001). No significant differences were found in cardiopulmonary bypass duration, associated procedures, or aortic cross-clamping times. Total operating time was 3.7+/-0.46 hours in group I compared with 3.4+/-0.6 hours in group II (p = 0.014). A similar incidence of cardiac, neurologic, infective, and renal complications between groups was found. Mean mediastinal drainage and mean blood transfusions (amount of blood transfused) per patient were greater in group II (p < 0.004 and p < 0.001, respectively). Twenty-five (62.5%) patients in group II and 15 (37.5%) patients in group I required postoperative blood transfusion (p = 0.04). Mechanical ventilation time was significantly longer in group II (6.2+/-1.8 hours versus 4.4+/-0.9 hours, p = 0.006). Five days after the surgical procedure, spirometric data analysis demonstrated a significantly lower total lung capacity and maximum inspiratory and expiratory pressures in group II compared with group I (p = 0.003, p = 0.007, and p < 0.001, respectively). Our results showed that ministernotomy had not only important cosmetic advantages but also beneficial effects in blood loss and transfusion, postoperative pain, and probably in sternal stability. Ministernotomy also improved recovery of respiratory function and allowed earlier extubation and hospital discharge.
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                Author and article information

                Contributors
                URI : https://loop.frontiersin.org/people/2771167/overviewRole: Role: Role: Role: Role: Role:
                URI : https://loop.frontiersin.org/people/2109855/overviewRole: Role:
                URI : https://loop.frontiersin.org/people/2709014/overviewRole: Role:
                Role: Role: Role:
                URI : https://loop.frontiersin.org/people/2236826/overviewRole: Role: Role:
                URI : https://loop.frontiersin.org/people/1964024/overviewRole: Role: Role:
                URI : https://loop.frontiersin.org/people/2698548/overviewRole: Role: Role: Role: Role:
                Journal
                Front Cardiovasc Med
                Front Cardiovasc Med
                Front. Cardiovasc. Med.
                Frontiers in Cardiovascular Medicine
                Frontiers Media S.A.
                2297-055X
                01 July 2024
                2024
                : 11
                : 1412829
                Affiliations
                [ 1 ]Department of Cardiothoracic Surgery, Augsburg University Hospital , Augsburg, Germany
                [ 2 ]Department of Anesthesiology and Surgical Intensive Care Medicine, Augsburg University Hospital , Augsburg, Germany
                Author notes

                Edited by: Francesco Formica, University of Parma, Italy

                Reviewed by: Alberto Albertini, Hesperia Hospital, Italy

                Tomas Holubec, University Hospital Frankfurt, Germany

                [* ] Correspondence: Sina Stock sina.stock@ 123456uk-augsburg.de
                Article
                10.3389/fcvm.2024.1412829
                11247003
                39011491
                e076c084-859d-4c6f-b505-8e0641c251f0
                © 2024 Berger Veith, Holst, Erfani, Pochert, Dumps, Girdauskas and Stock.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 05 April 2024
                : 13 June 2024
                Page count
                Figures: 1, Tables: 3, Equations: 0, References: 25, Pages: 7, Words: 0
                Funding
                The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
                Categories
                Cardiovascular Medicine
                Original Research
                Custom metadata
                Heart Surgery

                enhanced recovery after surgery (eras),enhanced recovery after cardiac surgery (eracs),minimally invasive cardiac surgery (mics),anterolateral mini-thoracotomy,partial sternotomy,mini-sternotomy,outcome

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