Biological characterization of sulfoxaflor, a novel insecticide

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The commercialization of new insecticides is important for ensuring that multiple effective product choices are available. In particular, new insecticides that exhibit high potency and lack insecticidal cross-resistance are particularly useful in insecticide resistance management (IRM) programs. Sulfoxaflor possesses these characteristics and is the first compound under development from the novel sulfoxamine class of insecticides.

Related collections

Most cited references 7

Record: found
Abstract: not found
Book: not found

Bayes and Empirical Bayes Methods for Data Analysis, Second Edition

Bradley Carlin, Thomas M. Louis (2000)

0 comments Cited 132 times – based on 0 reviews

Bookmark

Record: found
Abstract: found
Article: not found

Resistance of insect pests to neonicotinoid insecticides: current status and future prospects.

Ian Denholm, Ralf Nauen (2005)

The first neonicotinoid insecticide introduced to the market was imidacloprid in 1991 followed by several others belonging to the same chemical class and with the same mode of action. The development of neonicotinoid insecticides has provided growers with invaluable new tools for managing some of the world's most destructive crop pests, primarily those of the order Hemiptera (aphids, whiteflies, and planthoppers) and Coleoptera (beetles), including species with a long history of resistance to earlier-used products. To date, neonicotinoids have proved relatively resilient to the development of resistance, especially when considering aphids such as Myzus persicae and Phorodon humuli. Although the susceptibility of M. persicae may vary up to 20-fold between populations, this does not appear to compromise the field performance of neonicotinoids. Stronger resistance has been confirmed in some populations of the whitefly, Bemisia tabaci, and the Colorado potato beetle, Leptinotarsa decemlineata. Resistance in B- and Q-type B. tabaci appears to be linked to enhanced oxidative detoxification of neonicotinoids due to overexpression of monooxygenases. No evidence for target-site resistance has been found in whiteflies, whereas the possibility of target-site resistance in L. decemlineata is being investigated further. Strategies to combat neonicotinoid resistance must take account of the cross-resistance characteristics of these mechanisms, the ecology of target pests on different host plants, and the implications of increasing diversification of the neonicotinoid market due to a continuing introduction of new molecules. Copyright 2005 Wiley-Liss, Inc.

0 comments Cited 114 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.

Yuanming Zhu, Michael Loso, Gerald B Watson … (2011)

The discovery of sulfoxaflor [N-[methyloxido[1-[6-(trifluoromethyl)-3-pyridinyl]ethyl]-λ(4)-sulfanylidene] cyanamide] resulted from an investigation of the sulfoximine functional group as a novel bioactive scaffold for insecticidal activity and a subsequent extensive structure-activity relationship study. Sulfoxaflor, the first product from this new class (the sulfoximines) of insect control agents, exhibits broad-spectrum efficacy against many sap-feeding insect pests, including aphids, whiteflies, hoppers, and Lygus, with levels of activity that are comparable to those of other classes of insecticides targeting sap-feeding insects, including the neonicotinoids. However, no cross-resistance has been observed between sulfoxaflor and neonicotinoids such as imidacloprid, apparently the result of differences in susceptibility to oxidative metabolism. Available data are consistent with sulfoxaflor acting via the insect nicotinic receptor in a complex manner. These observations reflect the unique structure of the sulfoximines compared with neonicotinoids.

0 comments Cited 86 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: Pest Management Science

Abbreviated Title: Pest. Manag. Sci.

Publisher: Wiley-Blackwell

ISSN: 1526498X

Publication date Created: March 2011

Publication date (Print): March 14 2011

Volume: 67

Issue: 3

Pages: 328-334

Article

DOI: 10.1002/ps.2069

PubMed ID: 21308958

SO-VID: e0491ea9-ca9c-476f-9630-a09aede2483a

License:

http://doi.wiley.com/10.1002/tdm_license_1.1

History

Data availability:

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Biological characterization of sulfoxaflor, a novel insecticide

Read this article at

Abstract

Related collections

Bulletin Of Medical And Biological Research

Most cited references 7

Bayes and Empirical Bayes Methods for Data Analysis, Second Edition

Resistance of insect pests to neonicotinoid insecticides: current status and future prospects.

Discovery and characterization of sulfoxaflor, a novel insecticide targeting sap-feeding pests.

Author and article information

Journal

Article

History

Comments

Comment on this article

Similar content 3,365

Cited by 41

Most referenced authors 144