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SAK/PLK4 is required for centriole duplication and flagella development.
M Bettencourt-Dias
1 ,
A Rodrigues-Martins ,
L Carpenter ,
M Riparbelli ,
L Lehmann ,
M K Gatt ,
N Carmo ,
F Balloux ,
G Callaini ,
D M Glover
Dec 20 2005
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Abstract
SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known.