Type III Interferons, Viral Loads, Age, and Disease Severity in Young Children With Respiratory Syncytial Virus Infection.

Taveras, Jeanette; Garcia-Maurino, Cristina; Moore-Clingenpeel, Melissa; Xu, Zhaohui; Mertz, Sara E; Ye, Fang; Chen, Phyl; Cohen, Shira H.; Cohen, Daniel; Peeples, Mark E.; Ramilo, Octavio; Mejias, Asuncion

doi:10.1093/infdis/jiac404

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Type III Interferons, Viral Loads, Age, and Disease Severity in Young Children With Respiratory Syncytial Virus Infection.

Author(s): Jeanette Taveras ¹ , Cristina Garcia-Maurino ² , Melissa Moore-Clingenpeel ³ , Zhaohui Xu ² , Sara Mertz ² , Fang Ye ² , Phyl Chen ² , Shira H Cohen ² , Daniel Cohen ⁴ , Mark E Peeples ² , Octavio Ramilo ¹ ^, ² , Asuncion Mejias ¹ ^, ²

Publication date (Electronic): Dec 28 2022

Journal: The Journal of infectious diseases

Publisher: Oxford University Press (OUP)

Keywords: CXCL10 (IP-10), IFN-γ, RSV, cytokines, disease severity, innate immune response, mucosal interferons, type III interferon

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Abstract

The interplay among respiratory syncytial virus (RSV) loads, mucosal interferons (IFN), and disease severity in RSV-infected children is poorly understood.

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Journal ID (iso-abbrev): J Infect Dis

Title: The Journal of infectious diseases

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1537-6613

ISSN (Print): 0022-1899

Publication date (Electronic): Dec 28 2022

Volume: 227

Issue: 1

Affiliations

[1 ] Department of Pediatrics, Division of Infectious Diseases, Nationwide Children's Hospital and The Ohio State College of Medicine, Columbus, Ohio, USA.

[2 ] Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State College of Medicine, Columbus, Ohio, USA.

[3 ] Biostatistics Core, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

[4 ] Department of Pediatrics, Division of Emergency Medicine at Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA.

Article

Publisher Item ID: 6749015

DOI: 10.1093/infdis/jiac404

PubMed ID: 36200173

SO-VID: e0192587-95fa-4344-ad85-2f21f60fa76d

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Keywords: cytokines,RSV,IFN-γ,CXCL10 (IP-10),type III interferon,mucosal interferons,disease severity,innate immune response

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Keywords: cytokines, RSV, IFN-γ, CXCL10 (IP-10), type III interferon, mucosal interferons, disease severity, innate immune response

Type III Interferons, Viral Loads, Age, and Disease Severity in Young Children With Respiratory Syncytial Virus Infection.

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European Respiratory Society: COVID-19

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