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      Subjective responses to alcohol consumption as endophenotypes: advancing behavioral genetics in etiological and treatment models of alcoholism.

      Substance Use & Misuse
      Alcohol Drinking, genetics, Alcoholism, etiology, therapy, Genetics, Behavioral, Humans, Pharmacogenetics, Phenotype

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          Abstract

          Individual differences in subjective responses to alcohol consumption represent genetically mediated biobehavioral mechanisms of alcoholism risk (i.e., endophenotype). The objective of this review is three-fold: (1) to provide a critical review the literature on subjective response to alcohol and to discuss the rationale for its conceptualization as an endophenotype for alcoholism; (2) to examine the literature on the neurobiological substrates and associated genetic factors subserving individual differences in subjective response to alcohol; and (3) to discuss the treatment implications of this approach and to propose a framework for conceptualizing, and systematically integrating, endophenotypes into alcoholism treatment.

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          Author and article information

          Journal
          20590398
          10.3109/10826084.2010.482427

          Chemistry
          Alcohol Drinking,genetics,Alcoholism,etiology,therapy,Genetics, Behavioral,Humans,Pharmacogenetics,Phenotype

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