Spatio-temporal expression of Sox genes in murine palatogenesis.

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Abstract

Members of the Sox gene family play critical roles in many biological processes including organogenesis. We carried out comparative in situ hybridisation analysis of seventeen Sox genes (Sox1-14, 17, 18 and 21) during murine palatogenesis from initiation to fusion of the palatal shelves above the dorsal side of the tongue. At palatal shelf initiation (E12.5), the localized expression of six Sox genes (Sox2, 5, 6, 9, 12 and 13) was observed in the shelves, whereas Sox4 and Sox11 showed ubiquitious expression. During the down-growth of palatal shelves (E13.5), Sox4, Sox5, and Sox9 exhibited restricted expression to the interior side of the palatal shelves facing the tongue. Following elevation of the palatal shelves (E14.5), Sox2, Sox11 and Sox21 expression was present in the midline epithelial seam. We thus identify dynamic spatio-temporal expression of Sox gene family during the process of palatogenesis.

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Author and article information

Journal

Journal ID (iso-abbrev): Gene Expr Patterns

Title: Gene expression patterns : GEP

Publisher: Elsevier BV

ISSN (Electronic): 1872-7298

ISSN (Print): 1567-133X

Publication date (Electronic): July 2016

Volume: 21

Issue: 2

Affiliations

[1 ] Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Division of Oral and Maxillofacial Surgery, Department of Health Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.

[2 ] Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK; Oral Life Science, Research Center for Advanced Oral Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.

[3 ] Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK.

[4 ] Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK.

[5 ] Division of Oral and Maxillofacial Surgery, Department of Health Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.

[6 ] Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan.

[7 ] Division of Oral Anatomy, Department of Oral Biological Science, Niigata University, Graduate School of Medical and Dental Sciences, Niigata, Japan; Department of Craniofacial Development and Stem Cell Biology, Dental Institute, King's College London, Guy's Hospital, London Bridge, London, SE1 9RT, UK. Electronic address: atsushiohazama@dent.niigata-u.ac.jp.

Article

Publisher Item ID: S1567-133X(16)30017-5

DOI: 10.1016/j.gep.2016.05.002

PubMed ID: 27241892

SO-VID: dfa091c1-0d34-48e9-8c99-10af731b9fc4

History

Keywords: Palatal development,In situ hybridisation,Sox

Data availability:

Keywords: Palatal development, In situ hybridisation, Sox

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