Enhanced stimulation of anti-ovarian cancer CD8(+) T cells by dendritic cells loaded with nanoparticle encapsulated tumor antigen.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Dendritic cell (DC)-based cancer therapies are favored approaches to stimulate anti-tumor T-cell responses. Unfortunately, tolerance to tumor antigens is difficult to overcome. Biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NP) are effective reagents in the delivery of drugs and tumor-associated antigens (TAA). In this study, we assessed the capacity of a PLGA NP-based delivery system to augment CD8 T-cell responses to ovarian cancer TAA.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Am. J. Reprod. Immunol.

Title: American journal of reproductive immunology (New York, N.Y. : 1989)

Publisher: Wiley

ISSN (Electronic): 1600-0897

ISSN (Print): 1046-7408

Publication date (Electronic): Jun 2011

Volume: 65

Issue: 6

Affiliations

[1 ] Department of Dermatology, Yale University, New Haven, CT 06520, USA.

Article

Mid ID: NIHMS257695

DOI: 10.1111/j.1600-0897.2010.00968.x

PMC ID: 3082607

PubMed ID: 21241402

SO-VID: df3201c2-97d2-4228-bbb9-c2d804f4faa7

History

Data availability:

Comments

Comment on this article

scite_

0

Smart Citations

0

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Cited by 19

See all cited by