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Diversity-Oriented Synthesis of 13- to 18-Membered Macrolactams via Ring-Closing Metathesis
October 07 2011
October 07 2011
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Abstract
An efficient build/couple/pair approach to diversity-oriented synthesis was employed
to access several structurally complex macrolactams. In this paper, we describe the
successful evaluation of ring-closing metathesis toward the systematic generation
of skeletal diversity. By appropriately varying the nature and chain length of the
alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.