For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
0
views
12
references
 Top references
cited by
0
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      19
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Urgent health concerns: Clinical issues associated with accidental ingestion of new metal-blade-containing sticks for heated tobacco products

      case-report

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          INTRODUCTION

          Recently, a concerning pattern has emerged in clinical settings, drawing attention to the potential health risks associated with the accidental ingestion, mostly by children, of a new Heated Tobacco Product (HTP) stick, which contains a sharp metal blade inside.

          METHODS

          Following a webinar of the Joint Action on Tobacco Control 2 project, where data on adverse health incidents related to novel tobacco and nicotine products from EU Member States were presented, the Milan Poison Control Center (PCC) conducted a case series study on the accidental ingestion of blade-containing HTP sticks in Italy, between July 2023 and February 2024. The data in the medical records were analyzed to identify the age distribution, clinical presentation symptoms, performed diagnostic procedures, and medical management.

          RESULTS

          Overall, 40 cases of accidental ingestion of HTP sticks were identified and are described. A total of 33 (82.5%) children (infants and toddlers, mean age 12.3 ± 3.3 months) were hospitalized. Of these, 29 underwent abdominal X-rays, two children underwent esophagogastroduodenoscopy, and one child suffered from cut injuries to the tonsillar pillar and genian mucosa, requiring anesthesia for fibroscopy. The observed clinical cases associated with new HTP sticks containing a metal blade occurred over just eight months. This issue required the immediate implementation of corrective measures to mitigate health risks. The Ministry of Health issued an alert regarding the dangers related to the accidental ingestion of the stick and imposed more visible warnings on the package.

          CONCLUSIONS

          It is of the utmost importance to raise awareness among both the general public and medical practitioners to prevent further cases of accidental ingestion of HTP sticks by infants and toddlers, and ensure a prompt and informed response in emergency situations.

          Related collections

          Most cited references12

          • Record: found
          • Abstract: found
          • Article: not found

          Nicotinic plant poisoning.

          J Slaughter, Niels W L Schep, Derrick Beasley (2009)
          A wide range of plants contain nicotinic and nicotinic-like alkaloids. Of this diverse group, those that have been reported to cause human poisoning appear to have similar mechanisms of toxicity and presenting patients therefore have comparable toxidromes. This review describes the taxonomy and principal alkaloids of plants that contain nicotinic and nicotinic-like alkaloids, with particular focus on those that are toxic to humans. The toxicokinetics and mechanisms of toxicity of these alkaloids are reviewed and the clinical features and management of poisoning due to these plants are described. This review was compiled by systematically searching OVID MEDLINE and ISI Web of Science. This identified 9,456 papers, excluding duplicates, all of which were screened. Reviewed plants and their principal alkaloids. Plants containing nicotine and nicotine-like alkaloids that have been reported to be poisonous to humans include Conium maculatum, Nicotiana glauca and Nicotiana tabacum, Laburnum anagyroides, and Caulophyllum thalictroides. They contain the toxic alkaloids nicotine, anabasine, cytisine, n-methylcytisine, coniine, n-methylconiine, and gamma-coniceine. These alkaloids act agonistically at nicotinic-type acetylcholine (cholinergic) receptors (nAChRs). The nicotinic-type acetylcholine receptor can vary both in its subunit composition and in its distribution within the body (the central and autonomic nervous systems, the neuromuscular junctions, and the adrenal medulla). Agonistic interaction at these variable sites may explain why the alkaloids have diverse effects depending on the administered dose and duration of exposure. Nicotine and nicotine-like alkaloids are absorbed readily across all routes of exposure and are rapidly and widely distributed, readily traversing the blood-brain barrier and the placenta, and are freely distributed in breast milk. Metabolism occurs predominantly in the liver followed by rapid renal elimination. Following acute exposure, symptoms typically follow a biphasic pattern. The early phase consists of nicotinic cholinergic stimulation resulting in symptoms such as abdominal pain, hypertension, tachycardia, and tremors. The second inhibitory phase is delayed and often heralded by hypotension, bradycardia, and dyspnea, finally leading to coma and respiratory failure. Supportive care is the mainstay of management with primary emphasis on cardiovascular and respiratory support to ensure recovery. Exposure to plants containing nicotine and nicotine-like alkaloids can lead to severe poisoning but, with prompt supportive care, patients should make a full recovery.
          Article 0 comments Cited 27 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found
            Is Open Access

            Prevalence and reasons for use of Heated Tobacco Products (HTP) in Europe: an analysis of Eurobarometer data in 28 countries

            Anthony A. Laverty, Constantine I. Vardavas, Filippos Filippidis (2021)
            Background Heated Tobacco Products (HTP) are a relatively new class of tobacco products, with limited data on usage patterns. We assessed the prevalence and reasons for use among persons aged ≥15 years in 27 European Union member states and the United Kingdom· Methods The 2020 Eurobarometer (93·2) survey was analysed (n=28,300, aged ≥15). Multi-level regression analyses assessed socio-demographic differences in use while separate analyses investigated reasons for starting to use HTP. Results are presented as adjusted Odds Ratios (aOR) and weighted percentages with 95% Confidence Intervals (95%CI). Findings Overall, 6·5% (95% CI 6·1;7·0) of participants had ever used a HTP. 1·3% (1·1%;1·5%) of participants were current users of HTP, and 0·7% (0·6% to 0·9%) daily users. Current and former tobacco smokers were more likely than never tobacco smokers to use HTP (aOR 36·3 (22·9;57·5), and 7·3 (4·3;12·3) respectively. Youth aged 15-24 years of age were substantially more likely to report use, e.g. aOR for ever use=7·77 (6·56;9·21) compared to those aged ≥55 years. 51·3% of ever HTP users reported at least weekly concurrent use of combustible tobacco. Among those who reported ever use of HTP, but not e-cigarettes, the most popular reason for use was the perception that HTP are less harmful than smoking tobacco (39·5%), followed by use by friends (28·4%) and stopping or reducing smoking (28·2%). Interpretation Considerable numbers of people in the EU have ever used HTP, although current and daily use remains low. Current use is more common among younger people, and current and former smokers. Funding None
            Article 0 comments Cited 24 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Foreign body and caustic ingestions in children: A clinical practice guideline

              Salvatore Oliva, Claudio Romano, Paola De Angelis … (2020)
              Article 0 comments Cited 21 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Tob Prev Cessat
                Journal ID (iso-abbrev): Tob Prev Cessat
                Journal ID (publisher-id): TPC
                Title: Tobacco Prevention & Cessation
                Publisher: European Publishing on behalf of the European Network for Smoking and Tobacco Prevention (ENSP)
                ISSN (Electronic): 2459-3087
                Publication date (Electronic): 12 July 2024
                Publication date Collection: 2024
                Volume: 10
                Electronic Location Identifier: 10.18332/tpc/190634
                Affiliations
                [1 ]Poison Control Center of Niguarda Hospital, Milan, Italy
                [2 ]Istituto Superiore di Sanità, National Centre on Addiction and Doping, Rome, Italy
                [3 ]Ministry of Health, Rome, Italy
                [4 ]Centre for Health Protection, RIVM, National Institute for Public Health and the Environment, Bilthoven, the Netherlands
                [5 ]Federal Institute for Risk Assessment (BfR), Unit Product Research and Nanotechnology, Department Chemicals and Product Safety, Berlin, Germany
                Author notes
                CORRESPONDENCE TO Renata Solimini. National Centre on Addiction and Doping, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. E-mail: renata.solimini@ 123456iss.it ORCID iD: https://orcid.org/0000-0001-8737-4504
                Article
                Publisher ID: TPC-10-31
                DOI: 10.18332/tpc/190634
                PMC ID: 11243506
                PubMed ID: 39006098
                SO-VID: de29b2e7-8424-4914-bc6c-8725862fe3ec
                Copyright © © 2024 Moro PA. et al.
                License:

                This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License.

                History
                Date received : 22 April 2024
                Date revision received : 27 June 2024
                Date accepted : 30 June 2024
                Funding
                FUNDING The Joint Action on strengthening cooperation between interested Member States and the Commission in the area of Tobacco Control received funding from the European Union’s Health Program (2014-2020) under grant agreement N°101035968. The work of AH and CP is partially supported by the Dutch Ministry of Health, Welfare and Sports (VWS), project 5.7.1.
                Categories
                Subject: Short Report

                Keywords: heated tobacco product (htp),ingestion,children,metal blade,abdominal x-rays,endoscopy
                Data availability:
                Keywords: heated tobacco product (htp), ingestion, children, metal blade, abdominal x-rays, endoscopy

                Comments

                Comment on this article