Myricetin: A Dietary Molecule with Diverse Biological Activities

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Abstract

Myricetin is a common plant-derived flavonoid and is well recognised for its nutraceuticals value. It is one of the key ingredients of various foods and beverages. The compound exhibits a wide range of activities that include strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities. It displays several activities that are related to the central nervous system and numerous studies have suggested that the compound may be beneficial to protect against diseases such as Parkinson’s and Alzheimer’s. The use of myricetin as a preserving agent to extend the shelf life of foods containing oils and fats is attributed to the compound’s ability to protect lipids against oxidation. A detailed search of existing literature revealed that there is currently no comprehensive review available on this important molecule. Hence, the present work includes the history, synthesis, pharmaceutical applications and toxicity studies of myricetin. This report also highlights structure-activity relationships and mechanisms of action for various biological activities.

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Author and article information

Journal

Journal ID (nlm-ta): Nutrients

Journal ID (iso-abbrev): Nutrients

Journal ID (publisher-id): nutrients

Title: Nutrients

Publisher: MDPI

ISSN (Electronic): 2072-6643

Publication date (Electronic): 16 February 2016

Publication date Collection: February 2016

Volume: 8

Issue: 2

Electronic Location Identifier: 90

Affiliations

[1 ]Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria 0001, South Africa; SemwalDK@ 123456tut.ac.za (D.K.S.); SemwalRB@ 123456tut.ac.za (R.B.S.); CombrinckS@ 123456tut.ac.za (S.C.)

[2 ]SAMRC Herbal Drugs Research Unit, Faculty of Science, Tshwane University of Technology, Pretoria 0001, South Africa

Author notes

[* ]Correspondence: viljoenam@ 123456tut.ac.za ; Tel.: +27-12-382-6360; Fax: +27-12-382-6243

Article

Publisher ID: nutrients-08-00090

DOI: 10.3390/nu8020090

PMC ID: 4772053

PubMed ID: 26891321

SO-VID: de19850f-0cb7-46b9-803a-d2fc0e48f895

License:

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

History

Date received : 09 November 2015

Date accepted : 23 December 2015

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