Advanced applications of strontium-containing biomaterials in bone tissue engineering

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Abstract

Strontium (Sr) and strontium ranelate (SR) are commonly used therapeutic drugs for patients suffering from osteoporosis. Researches have showed that Sr can significantly improve the biological activity and physicochemical properties of materials in vitro and in vivo. Therefore, a large number of strontium containing biomaterials have been developed for repairing bone defects and promoting osseointegration. In this review, we provide a comprehensive overview of Sr-containing biomaterials along with the current state of their clinical use. For this purpose, the different types of biomaterials including calcium phosphate, bioactive glass, and polymers are discussed and provided future outlook on the fabrication of the next-generation multifunctional and smart biomaterials.

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Highlights

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Reviewed the different mechanisms of strontium promoting osteogenesis
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Different strontium containing biomaterials in bone tissue engineering
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Application potential of co-doping of strontium with other therapeutic ions materials
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Future research directions regarding strontium-containing biomaterials are prospected.

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Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Rinaldo Florencio-Silva, Gisela Sasso, Estela Sasso-Cerri … (2015)

Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process. This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis. An imbalance between bone resorption and formation can result in bone diseases including osteoporosis. Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells. For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts. Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption. The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology. It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue. In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling.

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Osteoblast-osteoclast interactions.

Xiao Chen, Zhongqiu Wang, Na Duan … (2018)

Bone homeostasis depends on the resorption of bones by osteoclasts and formation of bones by the osteoblasts. Imbalance of this tightly coupled process can cause diseases such as osteoporosis. Thus, the mechanisms that regulate communication between osteoclasts and osteoblasts are critical to bone cell biology. It has been shown that osteoblasts and osteoclasts can communicate with each other through direct cell-cell contact, cytokines, and extracellular matrix interaction. Osteoblasts can affect osteoclast formation, differentiation, or apoptosis through several pathways, such as OPG/RANKL/RANK, RANKL/LGR4/RANK, Ephrin2/ephB4, and Fas/FasL pathways. Conversely, osteoclasts also influence formation of bones by osteoblasts via the d2 isoform of the vacuolar (H+) ATPase (v-ATPase) V0 domain (Atp6v0d2), complement component 3a, semaphorin 4D or microRNAs. In addition, cytokines released from the resorbed bone matrix, such as TGF-β and IGF-1, also affect the activity of osteoblasts. Drugs could be developed by enhancing or restricting some of these interactions. Several reviews have been performed on the osteoblast-osteoclast communication. However, few reviews have shown the research advances in the recent years. In this review, we summarized the current knowledge on osteoblast-osteoclast communication.

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A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics.

Alexander Hoppe, Nusret Güldal, Aldo R. Boccaccini (2011)

Several inorganic materials such as special compositions of silicate glasses, glass-ceramics and calcium phosphates have been shown to be bioactive and resorbable and to exhibit appropriate mechanical properties which make them suitable for bone tissue engineering applications. However, the exact mechanism of interaction between the ionic dissolution products of such inorganic materials and human cells are not fully understood, which has prompted considerable research work in the biomaterials community during the last decade. This review comprehensively covers literature reports which have investigated specifically the effect of dissolution products of silicate bioactive glasses and glass-ceramics in relation to osteogenesis and angiogenesis. Particularly, recent advances made in fabricating dense biomaterials and scaffolds doped with trace elements (e.g. Zn, Sr, Mg, and Cu) and investigations on the effect of these elements on the scaffold biological performance are summarized and discussed in detail. Clearly, the biological response to artificial materials depends on many parameters such as chemical composition, topography, porosity and grain size. This review, however, focuses only on the ion release kinetics of the materials and the specific effect of the released ionic dissolution products on human cell behaviour, providing also a scope for future investigations and identifying specific research needs to advance the field. The biological performance of pure and doped silicate glasses, phosphate based glasses with novel specific compositions as well as several other silicate based compounds are discussed in detail. Cells investigated in the reviewed articles include human osteoblastic and osteoclastic cells as well as endothelial cells and stem cells. Copyright © 2011 Elsevier Ltd. All rights reserved.

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Author and article information

Contributors

Xiao Sheng

Chen Li

Zhonghan Wang

Yu Xu

Yang Sun

Weimin Zhang

He Liu

Jincheng Wang

Journal

Journal ID (nlm-ta): Mater Today Bio

Journal ID (iso-abbrev): Mater Today Bio

Title: Materials Today Bio

Publisher: Elsevier

ISSN (Electronic): 2590-0064

Publication date PMC-release: 15 April 2023

Publication date Collection: June 2023

Publication date (Electronic): 15 April 2023

Volume: 20

Electronic Location Identifier: 100636

Affiliations

[1]Department of Orthopedics, The Second Hospital of Jilin University, Changchun, 130041, Jilin, China

Author notes

[∗ ]Corresponding author. heliu@ 123456jlu.edu.cn

[1]

These authors have contributed equally to this work and share first authorship.

Article

Publisher Item ID: S2590-0064(23)00096-0 Publisher ID: 100636

DOI: 10.1016/j.mtbio.2023.100636

PMC ID: 10333686

SO-VID: dd8b7f40-4cd7-430d-b759-115dbdfc8dc2

License:

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

History

Date received : 2 February 2023

Date revision received : 4 April 2023

Date accepted : 14 April 2023

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Advanced applications of strontium-containing biomaterials in bone tissue engineering

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Most cited references 251

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

Osteoblast-osteoclast interactions.

A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics.

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Cited by 6

Most referenced authors 2,838