Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Bone metastasis is the leading cause of death in prostate cancer patients, for which there is currently no effective treatment. Since the bone microenvironment plays an important role in this process, attentions have been directed to the interactions between cancer cells and the bone microenvironment, including osteoclasts, osteoblasts, and bone stromal cells. Here, we explained the mechanism of interactions between prostate cancer cells and metastasis-associated cells within the bone microenvironment and further discussed the recent advances in targeted therapy of prostate cancer bone metastasis. This review also summarized the effects of bone microenvironment on prostate cancer metastasis and the related mechanisms, and provides insights for future prostate cancer metastasis studies.

Related collections

Most cited references 87

Record: found
Abstract: found
Article: found

Is Open Access

Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?

Rui-Mei Feng, Yi-Nan Zong, Su-Mei Cao … (2019)

Cancer is the leading cause of death in China and depicting the cancer pattern of China would provide basic knowhows on how to tackle it more effectively. In this study we have reviewed several reports of cancer burden, including the Global cancer statistics 2018 and Cancer statistics in China, 2015, along with the GLOBCAN 2018 online database, to investigate the differences of cancer patterns between China, the United States (USA) and the United Kingdom (UK). An estimated 4.3 million new cancer cases and 2.9 million new cancer deaths occurred in China in 2018. Compared to the USA and UK, China has lower cancer incidence but a 30% and 40% higher cancer mortality than the UK and USA, among which 36.4% of the cancer-related deaths were from the digestive tract cancers (stomach, liver, and esophagus cancer) and have relatively poorer prognoses. In comparison, the digestive cancer deaths only took up ≤ 5% of the total cancer deaths in either USA or UK. Other reasons for the higher mortality in China may be the low rate of early-stage cancers at diagnosis and non-uniformed clinical cancer treatment strategies performed by different regions. China is undergoing the cancer transition stage where the cancer spectrum is changing from developing country to developed country, with a rapidly increase cancer burden of colorectal, prostate, female breast cancers in addition to a high occurrence of infection-related and digestive cancers. The incidence of westernized lifestyle-related cancers in China (i.e. colorectal cancer, prostate, bladder cancer) has risen but the incidence of the digestive cancers has decreased from 2000 to 2011. An estimated 40% of the risk factors can be attributed to environmental and lifestyle factors either in China or other developed countries. Tobacco smoking is the single most important carcinogenic risk factor in China, contributing to ~ 24.5% of cancers in males. Chronic infection is another important preventable cancer contributor which is responsible for ~ 17% of cancers. Comprehensive prevention and control strategies in China should include effective tobacco-control policy, recommendations for healthier lifestyles, along with enlarging the coverage of effective screening, educating, and vaccination programs to better sensitize greater awareness control to the general public.

0 comments Cited 811 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Models, mechanisms and clinical evidence for cancer dormancy.

Julio Aguirre-Ghiso (2007)

Patients with cancer can develop recurrent metastatic disease with latency periods that range from years even to decades. This pause can be explained by cancer dormancy, a stage in cancer progression in which residual disease is present but remains asymptomatic. Cancer dormancy is poorly understood, resulting in major shortcomings in our understanding of the full complexity of the disease. Here, I review experimental and clinical evidence that supports the existence of various mechanisms of cancer dormancy including angiogenic dormancy, cellular dormancy (G0-G1 arrest) and immunosurveillance. The advances in this field provide an emerging picture of how cancer dormancy can ensue and how it could be therapeutically targeted.

0 comments Cited 531 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Normal bone anatomy and physiology.

Bart Clarke (2008)

This review describes normal bone anatomy and physiology as an introduction to the subsequent articles in this section that discuss clinical applications of iliac crest bone biopsy. The normal anatomy and functions of the skeleton are reviewed first, followed by a general description of the processes of bone modeling and remodeling. The bone remodeling process regulates the gain and loss of bone mineral density in the adult skeleton and directly influences bone strength. Thorough understanding of the bone remodeling process is critical to appreciation of the value of and interpretation of the results of iliac crest bone histomorphometry. Osteoclast recruitment, activation, and bone resorption is discussed in some detail, followed by a review of osteoblast recruitment and the process of new bone formation. Next, the collagenous and noncollagenous protein components and function of bone extracellular matrix are summarized, followed by a description of the process of mineralization of newly formed bone matrix. The actions of biomechanical forces on bone are sensed by the osteocyte syncytium within bone via the canalicular network and intercellular gap junctions. Finally, concepts regarding bone remodeling, osteoclast and osteoblast function, extracellular matrix, matrix mineralization, and osteocyte function are synthesized in a summary of the currently understood functional determinants of bone strength. This information lays the groundwork for understanding the utility and clinical applications of iliac crest bone biopsy.

0 comments Cited 515 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Contributors

Xiangyu Zhang:

ORCID: http://orcid.org/0000-0003-0170-0837

zhangxiangyu666@126.com

Journal

Journal ID (nlm-ta): Cancer Commun (Lond)

Journal ID (iso-abbrev): Cancer Commun (Lond)

Title: Cancer Communications

Publisher: BioMed Central (London )

ISSN (Electronic): 2523-3548

Publication date (Electronic): 21 November 2019

Publication date PMC-release: 21 November 2019

Publication date Collection: 2019

Volume: 39

Electronic Location Identifier: 76

Affiliations

ISNI 0000 0004 1797 7280, GRID grid.449428.7, Department of Pathology, Jining First People’s Hospital, , Jining Medical University, ; No. 6 Jiankang Road, Jining, 272000 Shandong P. R. China

Author information

Xiangyu Zhang http://orcid.org/0000-0003-0170-0837

Article

Publisher ID: 425

DOI: 10.1186/s40880-019-0425-1

PMC ID: 6873445

PubMed ID: 31753020

SO-VID: dd485a08-f4dd-43f3-8dbd-28e3b8ab2a55

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 23 August 2019

Date accepted : 13 November 2019

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: No. 81803097

Award ID: 81602727

Award Recipient : Xiangyu Zhang

Funded by: FundRef http://dx.doi.org/10.13039/501100007129, Natural Science Foundation of Shandong Province;

Award ID: No. ZR2017QH005

Award Recipient : Xiangyu Zhang

Custom metadata

Keywords: prostate cancer,bone metastasis,bone microenvironment,colonization,dormancy,reactivation,reconstruction,nuclear factor-κb ligand,androgen receptor,targeted therapy

Data availability:

Keywords: prostate cancer, bone metastasis, bone microenvironment, colonization, dormancy, reactivation, reconstruction, nuclear factor-κb ligand, androgen receptor, targeted therapy

Interactions between cancer cells and bone microenvironment promote bone metastasis in prostate cancer

Read this article at

Abstract

Related collections

Gamma Delta T cells

Most cited references 87

Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?

Models, mechanisms and clinical evidence for cancer dormancy.

Normal bone anatomy and physiology.

Author and article information

Contributors

Journal

Affiliations

Author information

Article

History

Funding

Categories

Custom metadata

Comments

Comment on this article

Similar content 626

Cited by 57

Most referenced authors 1,392