Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.

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Abstract

Interferon-γ (IFNγ) is the pivotal mediator in murine models of primary haemophagocytic lymphohistiocytosis (pHLH). Given the similarities between primary and secondary HLH (sec-HLH), including macrophage activation syndrome (MAS), we investigate the involvement of the IFNγ pathway in MAS by evaluating levels of IFNγ and of the induced chemokines, and their relation with laboratory parameters of MAS in systemic juvenile idiopathic arthritis (sJIA) patients with MAS and in a murine MAS model.

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Journal

Journal ID (iso-abbrev): Ann. Rheum. Dis.

Title: Annals of the rheumatic diseases

Publisher: BMJ

ISSN (Electronic): 1468-2060

ISSN (Print): 0003-4967

Publication date (Electronic): Jan 2017

Volume: 76

Issue: 1

Affiliations

[1 ] Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

[2 ] Novimmmune SA, Plan-les-Ouates, Geneva, Switzerland.

[3 ] University of Genoa, Istituto Giannina Gaslini, Genoa, Italy.

[4 ] Division of Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Article

Publisher Item ID: annrheumdis-2015-209020

DOI: 10.1136/annrheumdis-2015-209020

PubMed ID: 27296321

SO-VID: dcbe2b39-4933-498e-a987-a3a1decac4be

History

Keywords: Chemokines,Cytokines,Inflammation,Juvenile Idiopathic Arthritis

Data availability:

Keywords: Chemokines, Cytokines, Inflammation, Juvenile Idiopathic Arthritis

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