Design principles for therapeutic angiogenic materials

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Related collections

Most cited references 132

Record: found
Abstract: found
Article: not found

Angiogenesis in life, disease and medicine.

Peter Carmeliet (2005)

The growth of blood vessels (a process known as angiogenesis) is essential for organ growth and repair. An imbalance in this process contributes to numerous malignant, inflammatory, ischaemic, infectious and immune disorders. Recently, the first anti-angiogenic agents have been approved for the treatment of cancer and blindness. Angiogenesis research will probably change the face of medicine in the next decades, with more than 500 million people worldwide predicted to benefit from pro- or anti-angiogenesis treatments.

0 comments Cited 810 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Integrin ligands at a glance.

Jonathan Humphries, Adam Byron, Martin J. Humphries (2006)

0 comments Cited 468 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization.

George Davis, Donald Senger (2005)

The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane matrix that provides structural and organizational stability. During the onset of angiogenesis, this basement membrane matrix is degraded by proteinases, among which membrane-type matrix metalloproteinases (MT-MMPs) are particularly significant. As angiogenesis proceeds, ECM serves essential functions in supporting key signaling events involved in regulating EC migration, invasion, proliferation, and survival. Moreover, the provisional ECM serves as a pliable scaffold wherein mechanical guidance forces are established among distal ECs, thereby providing organizational cues in the absence of cell-cell contact. Finally, through specific integrin-dependent signal transduction pathways, ECM controls the EC cytoskeleton to orchestrate the complex process of vascular morphogenesis by which proliferating ECs organize into multicellular tubes with functional lumens. Thus, the composition of ECM and therefore the regulation of ECM degradation and remodeling serves pivotally in the control of lumen and tube formation and, finally, neovessel stability and maturation.

0 comments Cited 299 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: Nature Reviews Materials

Abbreviated Title: Nat. Rev. Mater.

Publisher: Springer Nature

ISSN (Electronic): 2058-8437

Publication date Created: January 11 2016

Publication date (Print): January 11 2016

Volume: 1

Issue: 1

Page: 15006

Article

DOI: 10.1038/natrevmats.2015.6

SO-VID: dcb42619-ff0f-4ddb-ae70-a30d953c8df5

History

Data availability:

Comments

Comment on this article

scite_

Cited by 54

See all cited by

Most referenced authors 2,441

See all reference authors

Design principles for therapeutic angiogenic materials

Read this article at

Abstract

Related collections

The FAIR data principles

Most cited references 132

Angiogenesis in life, disease and medicine.

Integrin ligands at a glance.

Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization.

Author and article information

Journal

Article

History

Comments

Comment on this article

Similar content 2,026

Cited by 54

Most referenced authors 2,441