Ferulic acid ameliorates ulcerative colitis in a rat model via the inhibition of two LPS-TLR4-NF-κB and NF-κB-INOS-NO signaling pathways and thus alleviating the inflammatory, oxidative and apoptotic conditions in the colon tissue.

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Abstract

Ulcerative colitis is a chronic inflammation of the colon. However, the common treatment for it is accompanied by many complications. Therefore, the present study was aimed to determine the ameliorative effects of ferulic acid on acetic acid-induced colitis in rat.

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Journal

Journal ID (iso-abbrev): Inflammopharmacology

Title: Inflammopharmacology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1568-5608

ISSN (Print): 0925-4692

Publication date (Electronic): Oct 2023

Volume: 31

Issue: 5

Affiliations

[1 ] Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.

[2 ] Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. rafieian@Yahoo.com.

Article

Publisher Item ID: 10.1007/s10787-023-01277-y

DOI: 10.1007/s10787-023-01277-y

PubMed ID: 37432553

SO-VID: dc2a2163-fba5-4118-8af0-7d92da4ca46a

History

Keywords: Apoptotic cytokines,Ulcerative colitis,Rat,Oxidative stress,Inflammatory cytokines,Ferulic acid

Data availability:

Keywords: Apoptotic cytokines, Ulcerative colitis, Rat, Oxidative stress, Inflammatory cytokines, Ferulic acid

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