Crosstalk of NF-κB/P65 and LncRNA HOTAIR-Mediated Repression of MUC1 Expression Contribute to Synergistic Inhibition of Castration-Resistant Prostate Cancer by Polyphyllin 1-Enzalutamide Combination Treatment.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Polyphyllin I (PPI), one of the steroidal saponins in Paris polyphylla, reportedly exhibits antitumor effects. However, the detailed mechanism underlying PPI, particularly in enhancing the effect of the androgen receptor inhibitor enzalutamide in controlling castration-resistant prostate cancer (CRPC) has not been explored.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Cell Physiol Biochem

Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Publisher: S. Karger AG

ISSN (Electronic): 1421-9778

ISSN (Print): 1015-8987

Publication date (Electronic): 2018

Volume: 47

Issue: 2

Affiliations

[1 ] Department of Urology Surgery, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.

[2 ] Laboratory of Tumor Biology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China.

Article

Publisher Item ID: 000490028

DOI: 10.1159/000490028

PubMed ID: 29807357

SO-VID: dc1c5561-d266-4b2a-906a-12e2d90ec61c

History

Keywords: HOTAIR,NF-κB/p65,CRPC cells,PPI ,Enzalutamide,MUC1

Data availability:

Keywords: HOTAIR, NF-κB/p65, CRPC cells, PPI , Enzalutamide, MUC1

Comments

Comment on this article

scite_

Cited by 14

See all cited by