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      • Record: found
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      Development of Animal Model for Studying Deep Second-Degree Thermal Burns

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          Abstract

          Thermal lesions were produced in 12 male Wistar rats, positioning a massive aluminum bar 10 mm in diameter (51 g), preheated to 99°C ± 2°C/10 min. on the back of each animal for 15 sec. After 7, 14, 21, and 28 days, animals were euthanized. The edema intensity was mild, with no bubble and formation of a thick and dry crust from the 3rd day. The percentage of tissue shrinkage at 28 days was 66.67 ± 1.66%. There was no sign of infection, bleeding, or secretion. Within 28 days reepithelialization was incomplete, with fibroblastic proliferation and moderate fibrosis and presence of modeled dense collagen fibers. It is concluded that the model established is applicable in obtaining deep second-degree thermal burns in order to evaluate the healing action of therapeutic agents of topical use.

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          Long-term outcome of children surviving massive burns.

          Douglas R Tompkins, A Nackel, Connie J Mulligan … (2000)
          Major advances in treatment of burn injuries in the last 20 years have made it possible to save the lives of children with massive burns, but whether their survival comes at the cost of impaired quality of life is unknown. To investigate the long-term quality of life in children who have survived massive burns. Retrospective, cross-sectional study conducted in a regional pediatric burn center. Eighty subjects who were younger than 18 years at the time of injury, who survived massive burns involving > or =70% of the body surface, and who were admitted to the burn center between 1969 and 1992 were evaluated an average (SD) of 14.7 (6.0) years after injury. Short Form 36 (SF-36) scores of the 60 patients aged at least 14 years were compared with national norms and the impact of clinical variables on individual domain scores was assessed. The SF-36 domain scores of the study patients, who had survived massive burns at a mean (SD) age of 8.8 (5.5) years, were generally similar to the normal population). However, 15% and 20% of the burn patients had scores in the physical functioning and physical role domains, respectively, that were more than 2 SDs below the relevant norm, indicating that a few patients had continuing serious physical disability. Better functional status of the family predicted a higher score in physical role (P = .04). The child's early reintegration with preburn activities predicted higher scores in general health (P = .03), physical functioning (P = .003), and physical role (P = .01). Children followed up consistently in the multidisciplinary burn clinic for 2 years had higher physical functioning (P = .04). In this study, while some children surviving severe burns had lingering physical disability, most had a satisfying quality of life. Comprehensive burn care that included experienced multidisciplinary aftercare played an important role in recovery.
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            Anesthesiologia veterinária: Farmacologia e técnicas

            F Massone, F. MASSONE, _______ (1994)
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              New technologies for burn wound closure and healing--review of the literature.

              S B Gunn, C Hayek, B Atiyeh (2005)
              Methods for handling burn wounds have changed in recent decades. Increasingly, aggressive surgical approach with early tangential excision and wound closure is being applied leading to improvement in mortality rates of burn victims. Autografts from uninjured skin remain the mainstay of treatment. Autologous skin graft, however, has limited availability and is associated with additional morbidity and scarring. Severe burn patients invariably lack sufficient adequate skin donor sites requiring alternative methods of skin replacement. The present review summarizes available replacement technologies.
              Article 0 comments Cited 33 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Biomed Biotechnol
                Journal ID (iso-abbrev): J. Biomed. Biotechnol
                Journal ID (publisher-id): JBB
                Title: Journal of Biomedicine and Biotechnology
                Publisher: Hindawi Publishing Corporation
                ISSN (Print): 1110-7243
                ISSN (Electronic): 1110-7251
                Publication date (Print): 2012
                Publication date (Electronic): 29 March 2012
                Volume: 2012
                Electronic Location Identifier: 460841
                Affiliations
                1Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil
                2Programa de Pós-Graduação em Biociência Animal, Universidade Federal Rural de Pernambuco, 52171-900 Recife, PE, Brazil
                3Departamento de Patologia, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil
                4Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil
                Author notes
                *Danielle dos Santos Tavares Pereira: dstpereira@ 123456yahoo.com.br

                Academic Editor: Monica Fedele

                Article
                DOI: 10.1155/2012/460841
                PMC ID: 3379528
                PubMed ID: 22736951
                SO-VID: dbb63a7d-e8f8-4ee1-ad1e-bf86e36240f8
                Copyright © Copyright © 2012 Danielle dos Santos Tavares Pereira et al.
                License:

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 9 January 2012
                Date revision received : 9 March 2012
                Date accepted : 13 March 2012
                Categories
                Subject: Methodology Report

                ScienceOpen disciplines: Molecular medicine
                Data availability:
                ScienceOpen disciplines: Molecular medicine

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