56
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Many drugs, including proton pump inhibitors and certain antidepressants, are metabolized by the polymorphic cytochrome P450 (CYP) 2C19 enzyme. A significant portion of extensive metabolizers do not reach appropriate drug levels, and our objective was to investigate any genetic background.

          Related collections

          Author and article information

          Journal
          Clin Pharmacol Ther
          Clinical pharmacology and therapeutics
          Elsevier BV
          0009-9236
          0009-9236
          Jan 2006
          : 79
          : 1
          Affiliations
          [1 ] Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm. Sarah.Sim@ki.se
          Article
          S0009-9236(05)00461-3
          10.1016/j.clpt.2005.10.002
          16413245
          db67be77-70b4-409a-a606-a7356d3df381
          History

          Comments

          Comment on this article

          scite_
          0
          0
          0
          0
          Smart Citations
          0
          0
          0
          0
          Citing PublicationsSupportingMentioningContrasting
          View Citations

          See how this article has been cited at scite.ai

          scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

          Similar content304

          Cited by146