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      • Record: found
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      Review of biosensing with whispering-gallery mode lasers

      review-article

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          Abstract

          Lasers are the pillars of modern optics and sensing. Microlasers based on whispering-gallery modes (WGMs) are miniature in size and have excellent lasing characteristics suitable for biosensing. WGM lasers have been used for label-free detection of single virus particles, detection of molecular electrostatic changes at biointerfaces, and barcode-type live-cell tagging and tracking. The most recent advances in biosensing with WGM microlasers are described in this review. We cover the basic concepts of WGM resonators, the integration of gain media into various active WGM sensors and devices, and the cutting-edge advances in photonic devices for micro- and nanoprobing of biological samples that can be integrated with WGM lasers.

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          Quantum dots versus organic dyes as fluorescent labels.

          Ute Resch-Genger, Markus Grabolle, Sara Cavaliere-Jaricot … (2008)
          Suitable labels are at the core of Luminescence and fluorescence imaging and sensing. One of the most exciting, yet also controversial, advances in label technology is the emerging development of quantum dots (QDs)--inorganic nanocrystals with unique optical and chemical properties but complicated surface chemistry--as in vitro and in vivo fluorophores. Here we compare and evaluate the differences in physicochemical properties of common fluorescent labels, focusing on traditional organic dyes and QDs. Our aim is to provide a better understanding of the advantages and limitations of both classes of chromophores, to facilitate label choice and to address future challenges in the rational design and manipulation of QD labels.
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            Zero-mode waveguides for single-molecule analysis at high concentrations.

            M Levene, J Korlach, S W Turner … (2003)
            Optical approaches for observing the dynamics of single molecules have required pico- to nanomolar concentrations of fluorophore in order to isolate individual molecules. However, many biologically relevant processes occur at micromolar ligand concentrations, necessitating a reduction in the conventional observation volume by three orders of magnitude. We show that arrays of zero-mode waveguides consisting of subwavelength holes in a metal film provide a simple and highly parallel means for studying single-molecule dynamics at micromolar concentrations with microsecond temporal resolution. We present observations of DNA polymerase activity as an example of the effectiveness of zero-mode waveguides for performing single-molecule experiments at high concentrations.
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              Stimulated Optical Radiation in Ruby

              T. MAIMAN (1960)
              Article 0 comments Cited 244 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Nikita Toropov:
                ORCID: http://orcid.org/0000-0002-0297-3661
                n.toropov@exeter.ac.uk
                Frank Vollmer: f.vollmer@exeter.ac.uk
                Journal
                Journal ID (nlm-ta): Light Sci Appl
                Journal ID (iso-abbrev): Light Sci Appl
                Title: Light, Science & Applications
                Publisher: Nature Publishing Group UK (London )
                ISSN (Print): 2095-5545
                ISSN (Electronic): 2047-7538
                Publication date (Electronic): 26 February 2021
                Publication date PMC-release: 26 February 2021
                Publication date Collection: 2021
                Volume: 10
                Electronic Location Identifier: 42
                Affiliations
                [1 ]GRID grid.8391.3, ISNI 0000 0004 1936 8024, Department of Physics and Astronomy, Living Systems Institute, , University of Exeter, ; Exeter, EX4 4QD UK
                [2 ]GRID grid.9499.d, ISNI 0000 0001 2097 3940, Departamento de Química, Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas, , Universidad Nacional de La Plata, ; La Plata, 1900 Argentina
                Author information
                http://orcid.org/0000-0002-0297-3661
                http://orcid.org/0000-0003-1617-7292
                http://orcid.org/0000-0002-2476-6794
                http://orcid.org/0000-0003-3393-358X
                Article
                Publisher ID: 471
                DOI: 10.1038/s41377-021-00471-3
                PMC ID: 7910454
                PubMed ID: 33637696
                SO-VID: db5f3d3c-cdb1-4d00-a1ad-9d93f65a62f8
                Copyright © © The Author(s) 2021
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                Date received : 25 August 2020
                Date revision received : 4 January 2021
                Date accepted : 9 January 2021
                Funding
                Funded by: FundRef https://doi.org/10.13039/501100000266, RCUK | Engineering and Physical Sciences Research Council (EPSRC);
                Award ID: EP/T002875/1
                Award ID: EP/R031428/1
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/501100000268, RCUK | Biotechnology and Biological Sciences Research Council (BBSRC);
                Award ID: BB/R022178/1
                Award Recipient :
                Categories
                Subject: Review Article
                Custom metadata
                issue-copyright-statement © The Author(s) 2021

                Keywords: imaging and sensing,biophotonics,optical sensors
                Data availability:
                Keywords: imaging and sensing, biophotonics, optical sensors

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