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      WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections

      review-article
      1 , , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 2 , 2 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 7 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 65 , 50 , 78 , 79 , 80 , 81 , 82 , 79 , 80 , 83
      World Journal of Emergency Surgery : WJES
      BioMed Central
      Skin and soft-tissue infections, Necrotizing soft-tissue infections, Necrotizing infections

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          Abstract

          Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections.

          Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs.

          An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting evidence was shared by an international task force with different clinical backgrounds.

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          Most cited references105

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          Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

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            Severe Sepsis and Septic Shock

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              Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children.

              Evidence-based guidelines for the management of patients with methicillin-resistant Staphylococcus aureus (MRSA) infections were prepared by an Expert Panel of the Infectious Diseases Society of America (IDSA). The guidelines are intended for use by health care providers who care for adult and pediatric patients with MRSA infections. The guidelines discuss the management of a variety of clinical syndromes associated with MRSA disease, including skin and soft tissue infections (SSTI), bacteremia and endocarditis, pneumonia, bone and joint infections, and central nervous system (CNS) infections. Recommendations are provided regarding vancomycin dosing and monitoring, management of infections due to MRSA strains with reduced susceptibility to vancomycin, and vancomycin treatment failures.
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                Author and article information

                Contributors
                massimosartelli@gmail.com
                federico.coccolini@unipi.it
                y_kluger@rambam.health.gov.il
                ervisagastra@yahoo.com
                fabuzidan@uaeu.ac.ae
                ashrafabbaas@hotmail.com
                aiace63@gmail.com
                adesunkanmi@yahoo.com
                augustin.goran@gmail.com
                Rbalam@hadassah.org.il
                oubaraket@gmail.com
                walt@biffl.com
                marco.ceresoli89@gmail.com
                elisabetta.cerutti@ospedaliriuniti.marche.it
                ochiara@yahoo.com
                enrico.cicuttin01@universitadipavia.it
                massimo.chiarugi@med.unipi.it
                raulcoimbra62@yahoo.com
                danielacorsi2@gmail.com
                francescocortese@gmail.com
                yunfengcuidoctor@aliyun.com
                Dimitrios.Damaskos@nhslothian.scot.nhs.uk
                nic.deangelis@yahoo.it
                sam.delibey@gmail.com
                zdemetr@yahoo.com
                desimone.belinda@gmail.com
                s.w.dejonge@amc.uva.nl
                stefano932@gmail.com
                salo75@inwind.it
                tmduanemd@yahoo.com
                paola.fugazzola@gmail.com
                jmgalante@ucdavis.edu
                wghnnam@gmail.com
                georgiokas@yahoo.com
                caxiaogomes@gmail.com
                Ewen.Griffiths@uhb.nhs.uk
                hardcastle@ukzn.ac.za
                Andreas.Hecker@chiru.med.uni-giessen.de
                t.herzog@klinikum-bochum.de
                alekara@sbb.rs
                vladimirkhokha@gmail.com
                kim.peter.p01@gmail.com
                erythrokim@paik.ac.kr
                Andrew.Kirkpatrick@albertahealthservices.ca
                victorywkong@yahoo.com
                renolkoshy@gmail.com
                Kenji.Inaba@med.usc.edu
                kararda@yahoo.com
                raoivatury@gmail.com
                labricciosafrancesco@gmail.com
                justnleeyy@gmail.com
                Ari.Leppaniemi@hus.fi
                aalitvin@gmail.com
                dl.davideluppi@gmail.com
                ronmaier@uw.edu
                drmarinis@gmail.com
                drsanjay.marwah@gmail.com
                mesina.cristian@doctor.com
                ernest.moore@dhha.org
                frederick.moore@surgery.ufl.edu
                negoiionut@gmail.com
                tunde_olaoye_dr@yahoo.com
                ordonezcarlosa@gmail.com
                mouaqit3001@gmail.com
                peitzmanab@upmc.edu
                gennaro.perrone82@gmail.com
                tadeja.pintar@kclj.si
                pep2pe@gmail.com
                mauropodda@ymail.com
                kemrasa@gmail.com
                Julivalribeiro@gmail.com
                gabyrodricks@gmail.com
                dr.inesrubio@gmail.com
                sall_i17@yahoo.fr
                drnori77@gmail.com
                robert.sawyer@med.wmich.edu
                vgshelat@rediffmail.com
                michaelesugrue@gmail.com
                atarasconi@gmail.com
                matti.tolonen@hus.fi
                bruno.viaggi@gmail.com
                Andrea.celotti@asst-cremona.it
                claudio.casella@unibs.it
                lpagani.id@gmail.com
                sameerdhingra78@gmail.com
                gianluca.baiocchi@unibs.it
                faustocatena@gmail.com
                Journal
                World J Emerg Surg
                World J Emerg Surg
                World Journal of Emergency Surgery : WJES
                BioMed Central (London )
                1749-7922
                15 January 2022
                15 January 2022
                2022
                : 17
                : 3
                Affiliations
                [1 ]Department of Surgery, Macerata Hospital, Macerata, Italy
                [2 ]GRID grid.144189.1, ISNI 0000 0004 1756 8209, Department of General, Emergency and Trauma Surgery, , Pisa University Hospital, ; Pisa, Italy
                [3 ]GRID grid.413731.3, ISNI 0000 0000 9950 8111, Department of General Surgery, , Rambam Health Care Campus, ; Haifa, Israel
                [4 ]General Surgery Department, Regional Hospital of Durres, Durres, Albania
                [5 ]GRID grid.43519.3a, ISNI 0000 0001 2193 6666, Department of Surgery, College of Medicine and Health Sciences, , UAE University, ; Al-Ain, United Arab Emirates
                [6 ]GRID grid.469958.f, Department of General and Emergency Surgery Faculty of Medicine, , Mansoura University Hospital, ; Mansoura, Egypt
                [7 ]GRID grid.8982.b, ISNI 0000 0004 1762 5736, Department of Surgery, Fondazione IRCCS Policlinico San Matteo, , University of Pavia, ; Pavia, Italy
                [8 ]GRID grid.10824.3f, ISNI 0000 0001 2183 9444, Department of Surgery, Faculty of Clinical Sciences, College of Health Sciences, , Obafemi Awolowo University, ; Ile-Ife, Osun State Nigeria
                [9 ]GRID grid.412688.1, ISNI 0000 0004 0397 9648, Department of Surgery, , University Hospital Centre Zagreb, ; Zagreb, Croatia
                [10 ]GRID grid.17788.31, ISNI 0000 0001 2221 2926, Trauma and Acute Care Surgery Unit, , Hadassah Hebrew University Medical Center, ; Jerusalem, Israel
                [11 ]GRID grid.12574.35, ISNI 0000000122959819, Department of General Surgery Bizerte Hospital, Faculty of Medicine of Tunis, , University Tunis El Manar, ; Tunis, Tunisia
                [12 ]GRID grid.415401.5, Division of Trauma/Acute Care Surgery, , Scripps Clinic Medical Group, ; La Jolla, CA USA
                [13 ]GRID grid.7563.7, ISNI 0000 0001 2174 1754, Emergency and General Surgery Department, , University of Milan-Bicocca, ; Milan, Italy
                [14 ]GRID grid.415845.9, Anesthesia and Transplant Surgical Intensive Care Unit, , Ospedali Riuniti, ; Ancona, Italy
                [15 ]GRID grid.4708.b, ISNI 0000 0004 1757 2822, Department of Pathophysiology, , ASST Niguarda Ca’Granda Hospital, University of Milano, ; Milan, Italy
                [16 ]GRID grid.43582.38, ISNI 0000 0000 9852 649X, Riverside University Health System, CECORC Research Center, , Loma Linda University, ; Loma Linda, USA
                [17 ]General Direction, Area Vasta 3, ASUR Marche, Macerata, Italy
                [18 ]Emergency Surgery Unit, San Filippo Neri’s Hospital, Rome, Italy
                [19 ]GRID grid.265021.2, ISNI 0000 0000 9792 1228, Department of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, , Tianjin Medical University, ; Tianjin, China
                [20 ]GRID grid.418716.d, ISNI 0000 0001 0709 1919, Department of Surgery, , Royal Infirmary of Edinburgh, ; Edinburgh, UK
                [21 ]Minimally Invasive and Robotic Digestive Surgery Unit, Regional General Hospital F. Miulli, Bari, Italy
                [22 ]GRID grid.410511.0, ISNI 0000 0001 2149 7878, Université Paris Est, UPEC, ; Creteil, France
                [23 ]GRID grid.412410.2, ISNI 0000 0001 0682 9061, Department of Surgery, , University Clinical Center of Tuzla, ; Tuzla, Bosnia and Herzegovina
                [24 ]Department General Surgery, Kipshidze Central University Hospital, Tbilisi, Georgia
                [25 ]GRID grid.418056.e, ISNI 0000 0004 1765 2558, Department of General, Digestive and Metabolic Minimally Invasive Surgery, , Centre Hospitalier Intercommunal De Poissy/St Germain en Laye, ; Poissy, France
                [26 ]GRID grid.7177.6, ISNI 0000000084992262, Department of Surgery, Academic Medical Center, , University of Amsterdam, ; Amsterdam, Netherlands
                [27 ]GRID grid.5133.4, ISNI 0000 0001 1941 4308, Clinical Department of Medical, Surgical and Health Sciences, , Trieste University, ; Trieste, Italy
                [28 ]Department of General Surgery, “Madonna del Soccorso” San Benedetto del Tronto Hospital, San Benedetto del Tronto, Italy
                [29 ]GRID grid.429044.f, ISNI 0000 0004 0402 1407, Department of Surgery, , Texas Health Resources, ; Ft Worth, TX USA
                [30 ]GRID grid.27860.3b, ISNI 0000 0004 1936 9684, Division of Trauma and Acute Care Surgery, Department of Surgery, , University of California Davis, ; Sacramento, CA USA
                [31 ]GRID grid.10251.37, ISNI 0000000103426662, Department of General Surgery, Mansoura Faculty of Medicine, , Mansoura University, ; Mansoura, Egypt
                [32 ]GRID grid.5216.0, ISNI 0000 0001 2155 0800, Second Department of Surgery, , Aretaieion University Hospital, National and Kapodistrian University of Athens, ; Athens, Greece
                [33 ]Department of Surgery, Hospital Universitário Terezinha de Jesus, Faculdade de Ciências Médicas E da Saúde de Juiz de Fora, Juiz de Fora, Brazil
                [34 ]GRID grid.415490.d, ISNI 0000 0001 2177 007X, Department of Upper GI Surgery, , Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, ; Birmingham, UK
                [35 ]Trauma Service, Inkosi Albert Luthuli Central Hospital and Department of Surgery, Nelson R Mandela School of Clinical Medicine, Durban, South Africa
                [36 ]GRID grid.411067.5, ISNI 0000 0000 8584 9230, Department of General and Thoracic Surgery, , University Hospital Giessen, ; Giessen, Germany
                [37 ]GRID grid.416438.c, Department of Surgery, , St. Josef Hospital, Ruhr University Bochum, ; Bochum, Germany
                [38 ]GRID grid.7149.b, ISNI 0000 0001 2166 9385, Surgical Clinic “Nikola Spasic”, , Faculty of Medicine University of Belgrade, ; Belgrade, Serbia
                [39 ]Department of Emergency Surgery, City Hospital, Mozyr, Belarus
                [40 ]GRID grid.251993.5, ISNI 0000000121791997, Department of Surgery, Jacobi Medical Center, , Albert Einstein College of Medicine, ; Bronx, NY USA
                [41 ]GRID grid.411633.2, ISNI 0000 0004 0371 8173, Department of Surgery, , Ilsan Paik Hospital, Inje University College of Medicine, ; Goyang, Republic of Korea
                [42 ]GRID grid.414959.4, ISNI 0000 0004 0469 2139, General, Acute Care, Abdominal Wall Reconstruction, and Trauma Surgery, , Foothills Medical Centre, ; Calgary, AB Canada
                [43 ]GRID grid.414386.c, ISNI 0000 0004 0576 7753, Department of Surgery, , Edendale Hospital, ; Pietermaritzburg, South Africa
                [44 ]GRID grid.412570.5, ISNI 0000 0004 0400 5079, Department of General Surgery, , University Hospital of Coventry and Warwickshire, ; Coventry, UK
                [45 ]GRID grid.42505.36, ISNI 0000 0001 2156 6853, Division of Trauma and Surgical Critical Care, Department of Surgery, , University of Southern California, ; Los Angeles, CA USA
                [46 ]GRID grid.411776.2, ISNI 0000 0004 0454 921X, Department of General Surgery, School of Medicine, , Istanbul Medeniyet University, ; Istanbul, Turkey
                [47 ]GRID grid.224260.0, ISNI 0000 0004 0458 8737, Department of Surgery, , Virginia Commonwealth University School of Medicine, ; Richmond, VA USA
                [48 ]Global Alliance for Infections in Surgery, Macerata, Italy
                [49 ]GRID grid.11875.3a, ISNI 0000 0001 2294 3534, School of Medical Sciences, , Universitiy Sains Malaysia, ; Kota Bharu, Kelantan Malaysia
                [50 ]GRID grid.15485.3d, ISNI 0000 0000 9950 5666, Abdominal Center, , Helsinki University Hospital and University of Helsinki, ; Helsinki, Finland
                [51 ]GRID grid.410686.d, ISNI 0000 0001 1018 9204, Department of Surgical Disciplines, , Immanuel Kant Baltic Federal University, Regional Clinical Hospital, ; Kaliningrad, Russia
                [52 ]Department of General and Emergency Surgery, ASMN, Reggio Emilia, Italy
                [53 ]GRID grid.34477.33, ISNI 0000000122986657, Department of Surgery, , University of Washington, ; Seattle, WA USA
                [54 ]GRID grid.417374.2, First Department of Surgery, , Tzaneion General Hospital, ; Piraeus, Greece
                [55 ]GRID grid.412572.7, ISNI 0000 0004 1771 1642, Department of Surgery, , Post-Graduate Institute of Medical Sciences, ; Rohtak, India
                [56 ]Second Surgical Clinic, Emergency Hospital of Craiova, Craiova, Romania
                [57 ]GRID grid.239638.5, ISNI 0000 0001 0369 638X, Ernest E Moore Shock Trauma Center at Denver Health, ; Denver, USA
                [58 ]GRID grid.15276.37, ISNI 0000 0004 1936 8091, Department of Surgery, Division of Acute Care Surgery, and Center for Sepsis and Critical Illness Research, , University of Florida College of Medicine, ; Gainesville, FL USA
                [59 ]Department of Surgery, Emergency Hospital of Bucharest, Bucharest, Romania
                [60 ]GRID grid.412975.c, ISNI 0000 0000 8878 5287, Department of Surgery, , University of Ilorin Teaching Hospital, ; Ilorin, Nigeria
                [61 ]GRID grid.477264.4, Division of Trauma and Acute Care Surgery, , Fundacion Valle del Lili, ; Cali, Colombia
                [62 ]GRID grid.8271.c, ISNI 0000 0001 2295 7397, Department of Surgery, , Universidad del Valle, ; Cali, Colombia
                [63 ]GRID grid.412817.9, ISNI 0000 0004 5938 8644, Department of Surgery, , Hassan II University Hospital, Medical School of Fez, Sidi Mohamed Benabdellah University, ; Fez, Morocco
                [64 ]GRID grid.21925.3d, ISNI 0000 0004 1936 9000, Department of Surgery, , University of Pittsburgh School of Medicine, UPMC-Presbyterian, ; Pittsburgh, USA
                [65 ]Department of Emergency Surgery, Parma Maggiore Hospital, Parma, Italy
                [66 ]GRID grid.29524.38, ISNI 0000 0004 0571 7705, Department of Surgery, , UMC Ljubljana, ; Ljubljana, Slovenia
                [67 ]GRID grid.419995.9, Department of Internal Medicine, Division of Infectious Disease, , ARNAS Civico-Di Cristina Hospital, ; Palermo, Italy
                [68 ]GRID grid.7763.5, ISNI 0000 0004 1755 3242, Department of General and Emergency Surgery, , Cagliari University Hospital, ; Cagliari, Italy
                [69 ]Department of Surgery, Anadolu Medical Center, Kocaeli, Turkey
                [70 ]GRID grid.414433.5, Infection Control, Hospital de Base, ; Brasília, DF Brazil
                [71 ]GRID grid.411639.8, ISNI 0000 0001 0571 5193, Department of General Surgery, , Kasturba Medical College and Hospital, Manipal Academy of Higher Education, ; Manipal, India
                [72 ]GRID grid.81821.32, ISNI 0000 0000 8970 9163, General Surgery Department, Colorectal Surgery Unit, , La Paz University Hospital, ; Madrid, Spain
                [73 ]General Surgery Department, Military Teaching Hospital, Dakar, Senegal
                [74 ]GRID grid.255464.4, ISNI 0000 0001 1011 3808, Department of Aeromedical Services for Emergency and Trauma Care, , Ehime University Graduate School of Medicine, ; Ehime, Japan
                [75 ]GRID grid.268187.2, ISNI 0000 0001 0672 1122, Department of Surgery, , Western Michigan University School of Medicine, ; Kalamazoo, MI USA
                [76 ]GRID grid.240988.f, ISNI 0000 0001 0298 8161, Department of General Surgery, , Tan Tock Seng Hospital, ; Singapore, Singapore
                [77 ]GRID grid.415900.9, ISNI 0000 0004 0617 6488, Donegal Clinical Research Academy Emergency Surgery Outcome Project, , Letterkenny University Hospital, ; Donegal, Ireland
                [78 ]GRID grid.24704.35, ISNI 0000 0004 1759 9494, Department of Anesthesiology, Neuro Intensive Care Unit, , Florence Careggi University Hospital, ; Florence, Italy
                [79 ]Department of Surgery, AAST Cremona, Cremona, Italy
                [80 ]GRID grid.7637.5, ISNI 0000000417571846, Department of Clinical and Experimental Sciences, , University of Brescia, ; Brescia, Italy
                [81 ]Department of Infectious Diseases, Bolzano Hospital, Bolzano, Italy
                [82 ]GRID grid.464629.b, ISNI 0000 0004 1775 2698, Department of Pharmacy Practice, , National Institute of Pharmaceutical Education and Research (NIPER), ; Hajipur, Bihar India
                [83 ]GRID grid.414682.d, ISNI 0000 0004 1758 8744, Department of Surgery, , “Bufalini” Hospital, ; Cesena, Italy
                Article
                406
                10.1186/s13017-022-00406-2
                8761341
                35033131
                db485270-f79a-4318-a85e-56df829dbc17
                © The Author(s) 2022

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 19 November 2021
                : 4 January 2022
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                Review
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                © The Author(s) 2022

                Surgery
                skin and soft-tissue infections,necrotizing soft-tissue infections,necrotizing infections

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