Modulation by chronic antipsychotic administration of PKA- and GSK3β-mediated pathways and the NMDA receptor in rat ventral midbrain.

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Abstract

Antipsychotics exert therapeutic effects by modulating various cellular signalling pathways and several types of receptors, including PKA- and GSK3β-mediated signalling pathways, and NMDA receptors. The ventral midbrain, mainly containing the ventral tegmental area (VTA) and substantia nigra (SN), are the nuclei with dopamine origins in the brain, which are also involved in the actions of antipsychotics. Whether antipsychotics can modulate these cellular pathways in the ventral midbrain is unknown.

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Author and article information

Journal

Journal ID (iso-abbrev): Psychopharmacology (Berl)

Title: Psychopharmacology

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1432-2072

ISSN (Print): 0033-3158

Publication date (Electronic): Sep 2019

Volume: 236

Issue: 9

Affiliations

[1 ] The Key Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou University Medical College, Yangzhou, 225001, China.

[2 ] Department of Pharmacy, Yangzhou University Medical College, Yangzhou, 225001, China.

[3 ] School of Medicine, University of Wollongong, Wollongong, NSW, 2522, Australia.

[4 ] Antipsychotic Research Laboratory, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia.

[5 ] School of Medicine, University of Wollongong, Wollongong, NSW, 2522, Australia. chao@uow.edu.au.

[6 ] Antipsychotic Research Laboratory, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, 2522, Australia. chao@uow.edu.au.

Article

Publisher Item ID: 10.1007/s00213-019-05243-x

DOI: 10.1007/s00213-019-05243-x

PubMed ID: 31053935

SO-VID: db3db831-48b1-4adb-aff7-cf32211b21b8

History

Keywords: Antipsychotics,GSK3β,NMDA receptor,PKA,Ventral midbrain

Data availability:

Keywords: Antipsychotics, GSK3β, NMDA receptor, PKA, Ventral midbrain

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