48
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      RNA interference: Applications and advances in insect toxicology and insect pest management.

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Since its discovery, RNA interference (RNAi) has revolutionized functional genomic studies due to its sequence-specific nature of post-transcriptional gene silencing. In this paper, we provide a comprehensive review of the recent literature and summarize the current knowledge and advances in the applications of RNAi technologies in the field of insect toxicology and insect pest management. Many recent studies have focused on identification and validation of the genes encoding insecticide target proteins, such as acetylcholinesterases, ion channels, Bacillus thuringiensis receptors, and other receptors in the nervous system. RNAi technologies have also been widely applied to reveal the role of genes encoding cytochrome P450 monooxygenases, carboxylesterases, and glutathione S-transferases in insecticide detoxification and resistance. More recently, studies have focused on understanding the mechanism of insecticide-mediated up-regulation of detoxification genes in insects. As RNAi has already shown great potentials for insect pest management, many recent studies have also focused on host-induced gene silencing, in which several RNAi-based transgenic plants have been developed and tested as proof of concept for insect pest management. These studies indicate that RNAi is a valuable tool to address various fundamental questions in insect toxicology and may soon become an effective strategy for insect pest management.

          Related collections

          Author and article information

          Journal
          Pestic Biochem Physiol
          Pesticide biochemistry and physiology
          1095-9939
          0048-3575
          May 2015
          : 120
          Affiliations
          [1 ] Department of Entomology, Kansas State University, Manhattan, KS 66506-4004, USA.
          [2 ] Department of Entomology, Kansas State University, Manhattan, KS 66506-4004, USA. Electronic address: kzhu@ksu.edu.
          Article
          S0048-3575(15)00003-6
          10.1016/j.pestbp.2015.01.002
          25987228
          db2811b3-278a-41d3-acd3-50ff9f8b7ab8
          Copyright © 2015 Elsevier Inc. All rights reserved.
          History

          Detoxification,Insect toxicology,Insecticide resistance,Pest management,RNA interference

          Comments

          Comment on this article

          scite_
          144
          1
          95
          0
          Smart Citations
          144
          1
          95
          0
          Citing PublicationsSupportingMentioningContrasting
          View Citations

          See how this article has been cited at scite.ai

          scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

          Similar content170

          Cited by45