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      Regulation of tumor metastasis by myeloid-derived suppressor cells.

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          Abstract

          Accumulation of pathologically activated immature myeloid cells with potent immune-suppressive activity is one of the major immunological hallmarks of cancer. In recent years, it became clear that in addition to their immune-suppressive activity, myeloid-derived suppressor cells (MDSCs) influence tumor progression in a variety of ways. They are directly implicated in the promotion of tumor metastases by participating in the formation of premetastatic niches, promoting angiogenesis and tumor cell invasion. In this review, we discuss recent data describing various roles of MDSCs in the formation of tumor metastases.

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          Author and article information

          Journal
          Annu. Rev. Med.
          Annual review of medicine
          1545-326X
          0066-4219
          2015
          : 66
          Affiliations
          [1 ] The Wistar Institute, Philadelphia, Pennsylvania 19104; email: tcondamine@wistar.org , iramachandran@wistar.org , dgabrilovich@wistar.org.
          Article
          NIHMS660680
          10.1146/annurev-med-051013-052304
          4324727
          25341012
          dad5f34f-2cef-4d39-a68f-fa47658bcf33
          History

          angiogenesis,chemotherapy,immune suppression,tumor cell invasion

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