Fine particulate matter exposure exacerbated nasal mucosal damage in allergic rhinitis mice via NLRP3 mediated pyroptosis.

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Abstract

The incidence of nasal allergy/allergic rhinitis (AR) is rising worldwide, which has become a serious public health problem. Epidemiological studies point that exposure to environmental PM2.5 is closely linked to AR aggravation, however, the exactly mechanism is not clear. This study was performed to reveal molecular mechanisms of PM2.5 -induced AR deterioration.

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Journal

Journal ID (iso-abbrev): Ecotoxicol Environ Saf

Title: Ecotoxicology and environmental safety

Publisher: Elsevier BV

ISSN (Electronic): 1090-2414

ISSN (Print): 0147-6513

Publication date (Electronic): Nov 16 2021

Volume: 228

Affiliations

[1 ] International Collaborative Laboratory for Air Pollution Health Effects and Intervention, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province 453003, China.

[2 ] Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Maternal and Child Health Care Hospital of Shandong Province, Shandong University, Shandong Province 250001, China.

[3 ] International Collaborative Laboratory for Air Pollution Health Effects and Intervention, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province 453003, China. Electronic address: wdwu2013@126.com.

Article

Publisher Item ID: S0147-6513(21)01110-6

DOI: 10.1016/j.ecoenv.2021.112998

PubMed ID: 34798361

SO-VID: dac1d39a-41a9-44d2-8840-a2fb25c3951c

History

Keywords: Allergic rhinitis,NLRP3,Nasal mucosa,PM(2.5),Pyroptosis

Data availability:

Keywords: Allergic rhinitis, NLRP3, Nasal mucosa, PM(2.5), Pyroptosis

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