A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression.

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Abstract

Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset of antidepressant effects within a few days and that are sustained would have an enormous impact on patient care. Converging lines of evidence suggest the role of the glutamatergic system in the pathophysiology and treatment of mood disorders.

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Journal

Journal ID (iso-abbrev): Arch Gen Psychiatry

Title: Archives of general psychiatry

Publisher: American Medical Association (AMA)

ISSN: 0003-990X

ISSN (Print): 0003-990X

Publication date (Electronic): Aug 2006

Volume: 63

Issue: 8

Affiliations

[1 ] Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, and Department of Health and Human Services, Bethesda, MD 20892, USA. zaratec@mail.nih.gov

Article

Publisher Item ID: 63/8/856

DOI: 10.1001/archpsyc.63.8.856

PubMed ID: 16894061

SO-VID: d9cab34b-bb3f-43cc-aee7-92ba516bf54c

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