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      Relative biological effectiveness (RBE) values for proton beam therapy.

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          Abstract

          Clinical proton beam therapy has been based on the use of a generic relative biological effectiveness (RBE) of 1.0 or 1.1, since the available evidence has been interpreted as indicating that the magnitude of RBE variation with treatment parameters is small relative to our abilities to determine RBEs. As substantial clinical experience and additional experimental determinations of RBE have accumulated and the number of proton radiation therapy centers is projected to increase, it is appropriate to reassess the rationale for the continued use of a generic RBE and for that RBE to be 1.0-1.1.

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          Author and article information

          Journal
          Int J Radiat Oncol Biol Phys
          International journal of radiation oncology, biology, physics
          Elsevier BV
          0360-3016
          0360-3016
          Jun 01 2002
          : 53
          : 2
          Affiliations
          [1 ] Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA. hpaganetti@partners.org
          Article
          S0360301602027542
          10.1016/s0360-3016(02)02754-2
          12023146
          d915bc68-06af-4d0d-9060-01691c55a4d1
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