For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
3
views
41
references
 Top references
cited by
8
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      231
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Risk of type 2 diabetes in metabolically healthy people in different categories of body mass index: an updated network meta-analysis of prospective cohort studies

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Introduction: Risk of diabetes mellitus type 2 (T2DM) is variable between individuals due to different metabolic phenotypes. In present network meta-analysis, we aimed to evaluate the risk of T2DM related with current definitions of metabolic health in different body mass index (BMI) categories.

          Methods: Relevant articles were collected by systematically searching PubMed and Scopus databases up to 20 March 2018 and for analyses we used a random-effects model. Nineteen prospective cohort studies were included in the analyses and metabolically healthy normal weight (MHNW) was considered as the reference group in direct comparison for calculating indirect comparisons in difference type of BMI categories.

          Results: Total of 199403 participants and 10388 cases from 19 cohort studies, were included in our network meta-analysis. Metabolically unhealthy obesity (MUHO) group poses highest risk for T2DM development with 10 times higher risk when is compared with MHNW (10.46 95% CI; 8.30, 13.18) and after that Metabolically unhealthy overweight (MUOW) individuals were at highest risk of T2DM with 7 times higher risk comparing with MHNW (7.25, 95% CI; 5.49, 9.57). Metabolically healthy overweight and obese (MHOW/MHO) individuals have (1.77, 95% CI; 1.33, 2.35) and (3.00, 95% CI; 2.33, 3.85) risk ratio for T2DM development in comparison with MHNW respectively.

          Conclusion: In conclusion we found that being classified as overweight and obese increased the risk of T2DM in comparison with normal weight. In addition, metabolically unhealthy (MUH) individuals are at higher risk of T2DM in all categories of BMI compared with metabolically healthy individuals.

          Related collections

          Most cited references41

          • Record: found
          • Abstract: found
          • Article: not found

          Race/ethnic difference in diabetes and diabetic complications.

          Sherita Hill Golden, N Spanakis (2013)
          Health disparities in diabetes and its complications and comorbidities exist globally. A recent Endocrine Society Scientific Statement described the Health Disparities in several endocrine disorders, including type 2 diabetes. In this review, we summarize that statement and provide novel updates on race/ethnic differences in children and adults with type 1 diabetes, children with type 2 diabetes, and in Latino subpopulations. We also review race/ethnic differences in the epidemiology of diabetes, prediabetes, and diabetes complications and mortality in the United States and globally. Finally, we discuss biological, behavioral, social, environmental, and health system contributors to diabetes disparities to identify areas for future preventive interventions.
          Article 0 comments Cited 202 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men.

            Johan Ärnlöv, Erik Ingelsson, Johan Sundström … (2010)
            The purpose of this study was to investigate associations between combinations of body mass index (BMI) categories and metabolic syndrome (MetS) and the risk of cardiovascular disease and death in middle-aged men. At age 50 years, cardiovascular risk factors were assessed in 1758 participants without diabetes in the community-based Uppsala Longitudinal Study of Adult Men (ULSAM). According to BMI-MetS status, they were categorized as normal weight (BMI 30 kg/m(2)) without MetS (n=30), or obese with MetS (n=66). During follow-up (median 30 years), 788 participants died, and 681 developed cardiovascular disease (composite of cardiovascular death or hospitalization for myocardial infarction, stroke, or heart failure). In Cox proportional-hazards models that adjusted for age, smoking, and low-density lipoprotein cholesterol, an increased risk for cardiovascular disease was observed in normal-weight participants with MetS (hazard ratio 1.63, 95% confidence interval 1.11 to 2.37), overweight participants without MetS (hazard ratio 1.52, 95% confidence interval 1.28 to 1.80), overweight participants with MetS (hazard ratio 1.74, 95% confidence interval 1.32 to 2.30), obese participants without MetS (hazard ratio 1.95, 95% confidence interval 1.14 to 3.34), and obese participants with MetS (hazard ratio 2.55, 95% confidence interval 1.81 to 3.58) compared with normal-weight individuals without MetS. These BMI-MetS categories significantly predicted total mortality rate in a similar pattern. Middle-aged men with MetS had increased risk for cardiovascular events and total death regardless of BMI status during more than 30 years of follow-up. In contrast to previous reports, overweight and obese individuals without MetS also had an increased risk. The present data refute the notion that overweight and obesity without MetS are benign conditions.
            Article 0 comments Cited 194 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Inflammation: the link between insulin resistance, obesity and diabetes

              P Dandona (2004)
              Article 0 comments Cited 180 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Cardiovasc Thorac Res
                Journal ID (iso-abbrev): J Cardiovasc Thorac Res
                Journal ID (publisher-id): J Cardiovasc Thorac Res
                Journal ID (pmc): JCVTR
                Journal ID (publisher-id): TBZMED
                Title: Journal of Cardiovascular and Thoracic Research
                Publisher: Tabriz University of Medical Sciences
                ISSN (Print): 2008-5117
                ISSN (Electronic): 2008-6830
                Publication date (Print): 2019
                Publication date (Electronic): 24 October 2019
                Volume: 11
                Issue: 4
                Pages: 254-263
                Affiliations
                1Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
                2Student’s Scientific Research Center, Tehran, Iran
                3Department of Cellular and molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
                4Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, ShahidBeheshti University of Medical Sciences, Tehran, Iran
                Author notes
                [* ] Corresponding Author: Atieh Mirzababaei, Email: ati_babaee@ 123456yahoo.com ; Hamed Kord Varkaneh, Email: hamedkord39@ 123456yahoo.com
                Author information
                https://orcid.org/0000-0003-3631-7723
                Article
                DOI: 10.15171/jcvtr.2019.43
                PMC ID: 6891044
                PubMed ID: 31824606
                SO-VID: d87657db-e7c4-44f5-9197-5f2c4b1fcd8f
                Copyright © © 2019 The Author(s)
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 07 January 2019
                Date accepted : 05 October 2019
                Page count
                Figures: 5, Tables: 1, References: 74, Pages: 10
                Categories
                Subject: Review Article

                Keywords: bmi,obesity,metabolic healthy,metabolic unhealthy,metabolic syndrome,diabetes mellitus type 2,t2dm
                Data availability:
                Keywords: bmi, obesity, metabolic healthy, metabolic unhealthy, metabolic syndrome, diabetes mellitus type 2, t2dm

                Comments

                Comment on this article

                scite_

                Similar content231

                See all similar

                Cited by7

                See all cited by

                Most referenced authors1,530

                See all reference authors