1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology

      research-article
      1 , 2 , 3 , 4 , 1 , 1 , 3 , 3 , 5 , 6 , 7 , 1 , 3 , 3 , 3 , 3 , 8 , 3 , 9 , 10 , 11 , 12 , 13 , 11 , 5 , 14 , 11 , 11 , 12 , 13 , 7 , 7 , 7 , 7 , The MetaCardis Consortium, 7 , 7 , 7 , 14 , 15 , 16 , 17 , 11 , 12 , 4 , 18 , 19 , 20 , 21 , 11 , 6 , 7 , 3 , 4 , 3 , 4 , , 1 , 7 , 22 ,
      Nature Communications
      Nature Publishing Group UK
      Microbiology, Endocrinology

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.

          Abstract

          Gut microbial metabolism of nutrients contributes to metabolic diseases, and the histidine metabolite imidazole propionate (ImP) is produced by type 2 diabetes (T2D) associated microbiome. Here the authors report that circulating ImP levels are increased in subjects with prediabetes or T2D in three European populations, and this increase associates with altered gut microbiota rather than dietary histidine.

          Related collections

          Most cited references64

          • Record: found
          • Abstract: found
          • Article: not found

          Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man.

          The steady-state basal plasma glucose and insulin concentrations are determined by their interaction in a feedback loop. A computer-solved model has been used to predict the homeostatic concentrations which arise from varying degrees beta-cell deficiency and insulin resistance. Comparison of a patient's fasting values with the model's predictions allows a quantitative assessment of the contributions of insulin resistance and deficient beta-cell function to the fasting hyperglycaemia (homeostasis model assessment, HOMA). The accuracy and precision of the estimate have been determined by comparison with independent measures of insulin resistance and beta-cell function using hyperglycaemic and euglycaemic clamps and an intravenous glucose tolerance test. The estimate of insulin resistance obtained by homeostasis model assessment correlated with estimates obtained by use of the euglycaemic clamp (Rs = 0.88, p less than 0.0001), the fasting insulin concentration (Rs = 0.81, p less than 0.0001), and the hyperglycaemic clamp, (Rs = 0.69, p less than 0.01). There was no correlation with any aspect of insulin-receptor binding. The estimate of deficient beta-cell function obtained by homeostasis model assessment correlated with that derived using the hyperglycaemic clamp (Rs = 0.61, p less than 0.01) and with the estimate from the intravenous glucose tolerance test (Rs = 0.64, p less than 0.05). The low precision of the estimates from the model (coefficients of variation: 31% for insulin resistance and 32% for beta-cell deficit) limits its use, but the correlation of the model's estimates with patient data accords with the hypothesis that basal glucose and insulin interactions are largely determined by a simple feed back loop.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites.

            A compelling set of links between the composition of the gut microbiota, the host diet, and host physiology has emerged. Do these links reflect cause-and-effect relationships, and what might be their mechanistic basis? A growing body of work implicates microbially produced metabolites as crucial executors of diet-based microbial influence on the host. Here, we will review data supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs). SCFAs can directly activate G-coupled-receptors, inhibit histone deacetylases, and serve as energy substrates. They thus affect various physiological processes and may contribute to health and disease.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              A metagenome-wide association study of gut microbiota in type 2 diabetes.

              Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, we developed a protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 60,000 type-2-diabetes-associated markers and established the concept of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.
                Bookmark

                Author and article information

                Contributors
                karine.clement@inserm.fr
                fredrik.backhed@wlab.gu.se
                Journal
                Nat Commun
                Nat Commun
                Nature Communications
                Nature Publishing Group UK (London )
                2041-1723
                18 November 2020
                18 November 2020
                2020
                : 11
                : 5881
                Affiliations
                [1 ]GRID grid.8761.8, ISNI 0000 0000 9919 9582, Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, ; 413 45 Gothenburg, Sweden
                [2 ]GRID grid.1649.a, ISNI 000000009445082X, Department of Medicine, Sahlgrenska University Hospital, ; Gothenburg, Sweden
                [3 ]INSERM, Nutrition and Obesities; Systemic Approaches (NutriOmics), Sorbonne Université, Paris, France
                [4 ]GRID grid.411439.a, ISNI 0000 0001 2150 9058, Assistance Publique Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Nutrition department, CRNH Ile de France, ; Paris, France
                [5 ]GRID grid.477396.8, Integromics Unit, Institute of Cardiometabolism and Nutrition, ; 75013 Paris, France
                [6 ]GRID grid.9647.c, ISNI 0000 0004 7669 9786, Medical Department III - Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, ; Leipzig, Germany
                [7 ]GRID grid.5254.6, ISNI 0000 0001 0674 042X, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, ; Blegdamsvej 3B, 2200 Copenhagen, Denmark
                [8 ]GRID grid.50550.35, ISNI 0000 0001 2175 4109, Assistance Publique Hôpitaux de Paris, Clinical Investigation Center Paris East, ; 75013 Paris, France
                [9 ]Assistance Publique Hôpitaux de Paris, Biochemistry and Hormonology Department, Tenon Hospital, 75020 Paris, France
                [10 ]GRID grid.419491.0, ISNI 0000 0001 1014 0849, Experimental and Clinical Research Center, A Cooperation of Charité-Universitätsmedizin and the Max-Delbrück Center, ; Berlin, Germany
                [11 ]GRID grid.462293.8, ISNI 0000 0004 0522 0627, Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, ; Paris, France
                [12 ]GRID grid.415751.3, Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, ; KU Leuven Leuven, Belgium
                [13 ]Center for Microbiology, VIB Leuven, Belgium
                [14 ]GRID grid.464114.2, Unité de Modélisation Mathématique et Informatique des Systèmes Complexes, UMMISCO, ; 93143 Bondy, France
                [15 ]Sorbonne Paris Cité Epidemiology and Statistics Research Centre (CRESS), U1153 Inserm, U1125, Inra, Cnam, University of Paris 13, Nutritional Epidemiology Research Team (EREN), 93017 Bobigny, France
                [16 ]GRID grid.7445.2, ISNI 0000 0001 2113 8111, Computational and Systems Medicine, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, ; London, SW7 2AZ UK
                [17 ]GRID grid.7445.2, ISNI 0000 0001 2113 8111, Genomic and Environmental Medicine, National Heart & Lung Institute, Faculty of Medicine, Imperial College London, ; London, SW3 6KY UK
                [18 ]GRID grid.431797.f, Biobyte Solutions GmbH, ; Bothestr. 142, 69117 Heidelberg, Germany
                [19 ]GRID grid.5371.0, ISNI 0000 0001 0775 6028, Department of Biology and Biological Engineering, Chalmers University of Technology, ; SE41128 Gothenburg, Sweden
                [20 ]GRID grid.4709.a, ISNI 0000 0004 0495 846X, Structural and Computational Biology, European Molecular Biology Laboratory, ; Heidelberg, Germany
                [21 ]GRID grid.4709.a, ISNI 0000 0004 0495 846X, Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, ; Heidelberg, Germany
                [22 ]GRID grid.1649.a, ISNI 000000009445082X, Department of Clinical Physiology, Region Västra Götaland, Sahlgrenska University Hospital, ; Gothenburg, Sweden
                [23 ]GRID grid.411439.a, ISNI 0000 0001 2150 9058, Assistance Publique Hôpitaux de Paris, Diabetes Department, Pitie-Salpêtrière Hospital, ; Paris, France
                [24 ]GRID grid.411439.a, ISNI 0000 0001 2150 9058, Assistance Publique Hôpitaux de Paris, Cardiology Department, Pitie-Salpêtrière Hospital, ; Paris, France
                [25 ]INRAE, Metagenopolis, Université Paris-Saclay, Jouy en Josas, France
                [26 ]GRID grid.411439.a, ISNI 0000 0001 2150 9058, Assistance Publique Hôpitaux de Paris, Pitie-Salpêtrière Hospital, Biochemistry Department of Metabolic Disorders, ; Paris, France
                [27 ]GRID grid.8547.e, ISNI 0000 0001 0125 2443, Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, ; Shanghai, China
                [28 ]GRID grid.465261.2, ISNI 0000 0004 1793 5929, Centre de Recherche Saint-Antoine, Sorbonne Université-INSERM UMR-S 938, IHU ICAN, ; Paris, France
                [29 ]GRID grid.411439.a, ISNI 0000 0001 2150 9058, Assistance Publique Hôpitaux de Paris, Endocrinology Department, Pitie-Salpêtrière Hospital, ; Paris, France
                [30 ]Department of Clinical Biochemistry, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
                [31 ]Assistance Publique Hôpitaux de Paris, Department of Pharmacology, Pitie-Salpêtrière Hospital, NICO Cardio-oncology Program, CIC-1421, INSERM, Sorbonne Université, Paris, France
                [32 ]GRID grid.410511.0, ISNI 0000 0001 2149 7878, PARCC, INSERM, Université de Paris, ; Paris, France
                [33 ]GRID grid.414093.b, Assistance Publique Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, CIC1418 and DMU CARTE, ; Paris, France
                [34 ]Integrative Phenomics, Paris, France
                Author information
                http://orcid.org/0000-0002-2066-7895
                http://orcid.org/0000-0002-7543-153X
                http://orcid.org/0000-0003-2450-0782
                http://orcid.org/0000-0001-8861-1305
                http://orcid.org/0000-0002-4616-7602
                http://orcid.org/0000-0001-5948-8993
                http://orcid.org/0000-0001-6350-8117
                http://orcid.org/0000-0003-3090-269X
                http://orcid.org/0000-0001-8748-3831
                http://orcid.org/0000-0001-9523-7024
                http://orcid.org/0000-0002-1337-041X
                http://orcid.org/0000-0002-9955-6003
                http://orcid.org/0000-0002-2627-833X
                http://orcid.org/0000-0002-7563-4046
                http://orcid.org/0000-0002-3321-3972
                http://orcid.org/0000-0002-2489-3355
                http://orcid.org/0000-0002-4871-8818
                Article
                19589
                10.1038/s41467-020-19589-w
                7676231
                33208748
                d869d27a-0ddc-4215-b9b5-c7b9429cb810
                © The Author(s) 2020

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 2 September 2019
                : 22 October 2020
                Funding
                Funded by: FundRef https://doi.org/10.13039/100011199, EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013));
                Award ID: 305312
                Award ID: 615362
                Award ID: 305312
                Award ID: 305312
                Award ID: 305312
                Award ID: 305312
                Award ID: 305312
                Award ID: 305312
                Award ID: 305312
                Award ID: 305312
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/100013279, Joint Programming Initiative A healthy diet for a healthy life (JPI A Healthy Diet for a Healthy Life);
                Award ID: 2017-01996_3
                Award ID: 2017-01996_3
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/501100001674, Fondation Leducq;
                Award ID: 17CVD01
                Award ID: 17CVD01
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/501100004359, Vetenskapsrådet (Swedish Research Council);
                Award ID: 2019-01599
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/501100003793, Hjärt-Lungfonden (Swedish Heart-Lung Foundation);
                Award ID: 20180600
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/501100004063, Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation);
                Award ID: 2017.0026
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/501100009708, Novo Nordisk Fonden (Novo Nordisk Foundation);
                Award ID: NNF19OC0057271
                Award ID: NNF17OC0028232
                Award ID: NNF15OC0016798
                Award Recipient :
                Funded by: FundRef https://doi.org/10.13039/501100011747, Novo Nordisk Foundation Center for Basic Metabolic Research (NovoNordisk Foundation Center for Basic Metabolic Research);
                Funded by: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
                Funded by: FundRef https://doi.org/10.13039/100007464, Torsten Söderbergs Stiftelse (Torsten Söderberg Foundation);
                Funded by: Swedish government and the county councils, the ALF-agreement (ALFGBG- 718101)
                Funded by: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
                Funded by: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
                Funded by: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
                Funded by: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
                Funded by: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
                Funded by: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
                Funded by: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
                Funded by: EC | EC Seventh Framework Programm | FP7 Ideas: European Research Council (FP7-IDEAS-ERC - Specific Programme: "Ideas" Implementing the Seventh Framework Programme of the European Community for Research, Technological Development and Demonstration Activities (2007 to 2013))
                Categories
                Article
                Custom metadata
                © The Author(s) 2020

                Uncategorized
                microbiology,endocrinology
                Uncategorized
                microbiology, endocrinology

                Comments

                Comment on this article