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      Ultrasonography for long-term evaluation of hyaluronic acid filler in the face: A technical report of 180 days of follow-up

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          Abstract

          Purpose

          In this study, we used ultrasonography to monitor the use of hyaluronic acid (HA) as a filler in the face for esthetic reasons. We monitored changes in the filler shape, distribution, and relationship with adjacent anatomical structures over a 180-day period.

          Materials and Methods

          Two patients each received an ultrasound-guided injection of HA, with different products and application sites for each patient. In 1 patient, the injection was administered in the angle of the mandible, while in the other, it was administered in the zygomatic region. The injection sites were monitored via ultrasonography at 24 hours, 30 days, and 180 days, at which times the imaging characteristics of the filler were observed. All injections were performed by the same professional, as were the ultrasound exams, which were conducted using the same equipment.

          Results

          In both cases, the HA fillers were visualized using ultrasound at all time points. Some differences were observed between the cases in the images and the distribution of the pockets of filler. In 1 case, the filler appeared as a dark hypoechoic region with well-defined contours, and the material was observed to have moved posteriorly by the 180-day mark. In the other case, the material appeared hyperechoic relative to the previous case and presented no noticeable changes in its anteroposterior distribution over time.

          Conclusion

          Based on these 2 cases, ultrasonography can be a complementary tool used to monitor facial fillers over the long term, allowing for the dynamic observation of different fillers.

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          Most cited references15

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          Global Aesthetics Consensus: Avoidance and Management of Complications from Hyaluronic Acid Fillers—Evidence- and Opinion-Based Review and Consensus Recommendations

          Background: Although the safety profile of hyaluronic acid fillers is favorable, adverse reactions can occur. Clinicians and patients can benefit from ongoing guidance on adverse reactions to hyaluronic acid fillers and their management. Methods: A multinational, multidisciplinary group of experts in cosmetic medicine convened the Global Aesthetics Consensus Group to review the properties and clinical uses of Hylacross and Vycross hyaluronic acid products and develop updated consensus recommendations for early and late complications associated with hyaluronic acid fillers. Results: The consensus panel provided specific recommendations focusing on early and late complications of hyaluronic acid fillers and their management. The impact of patient-, product-, and technique-related factors on such reactions was described. Most of these were noted to be mild and transient. Serious adverse events are rare. Early adverse reactions to hyaluronic acid fillers include vascular infarction and compromise; inflammatory reactions; injection-related events; and inappropriate placement of filler material. Among late reactions are nodules, granulomas, and skin discoloration. Most adverse events can be avoided with proper planning and technique. Detailed understanding of facial anatomy, proper patient and product selection, and appropriate technique can further reduce the risks. Should adverse reactions occur, the clinician must be prepared and have tools available for effective treatment. Conclusions: Adverse reactions with hyaluronic acid fillers are uncommon. Clinicians should take steps to further reduce the risk and be prepared to treat any complications that arise.
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            Basics of dermal filler rheology.

            Hyaluronic acid injectable fillers are the most widely used dermal fillers to treat facial volume deficits, providing long-term facial aesthetic enhancement outcomes for the signs of aging and/or facial contouring.
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              Injectable Fillers: Review of Material and Properties

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                Author and article information

                Journal
                Imaging Sci Dent
                Imaging Sci Dent
                ISD
                Imaging Science in Dentistry
                Korean Academy of Oral and Maxillofacial Radiology
                2233-7822
                2233-7830
                June 2020
                18 June 2020
                : 50
                : 2
                : 175-180
                Affiliations
                [1 ]Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
                [2 ]Hermes Pardini Group, Belo Horizonte, Brazil.
                [3 ]Nucleodonto, Brasília, Brazil.
                [4 ]Department of Dentistry, Oral Radiology, Pontifical Catholic University of Minas Gerais, Belo Horizonte, Brazil.
                Author notes
                Correspondence to: Prof. Micena Roberta Miranda Alves e Silva. Department of Morphology, Biological Sciences Institute, Federal University of Minas Gerais, Av. Antônio Carlos, 6627 - 31.270-901, Belo Horizonte, MG, Brazil. Tel) 55-31-3409-3003, micenarm@ 123456gmail.com
                Author information
                https://orcid.org/0000-0002-6074-5093
                https://orcid.org/0000-0001-6541-9281
                https://orcid.org/0000-0002-8425-5339
                https://orcid.org/0000-0001-9244-6859
                https://orcid.org/0000-0001-9467-5137
                https://orcid.org/0000-0002-6642-3650
                Article
                10.5624/isd.2020.50.2.175
                7314613
                d7997df2-c5c1-4355-b21e-effea59c3d33
                Copyright © 2020 by Korean Academy of Oral and Maxillofacial Radiology

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 11 September 2019
                : 11 February 2020
                : 13 February 2020
                Categories
                Technical Report

                Dentistry
                ultrasonography,esthetics,hyaluronic acid,dermal fillers
                Dentistry
                ultrasonography, esthetics, hyaluronic acid, dermal fillers

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