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Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors.
Michael L Nickerson
1 ,
Erich Jaeger ,
Yangu Shi ,
Jeffrey A Durocher ,
Sunil Mahurkar ,
David Zaridze ,
Vsevolod Matveev ,
Vladimir Janout ,
Hellena Kollarova ,
Vladimir Bencko ,
Marie Navratilova ,
Neonilia Szeszenia-Dabrowska ,
Dana Mates ,
Anush Mukeria ,
Ivana Holcatova ,
Laura S Schmidt ,
Jorge R Toro ,
Sara Karami ,
Rayjean Hung ,
Gary F Gerard ,
W Marston Linehan ,
Maria Merino ,
Berton Zbar ,
Paolo Boffetta ,
Paul Brennan ,
Nathaniel Rothman ,
Wong-Ho Chow ,
Frederic M Waldman ,
Lee E Moore
Aug 01 2008
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Abstract
To provide a comprehensive, thorough analysis of somatic mutation and promoter hypermethylation of the von Hippel-Lindau (VHL) gene in the cancer genome, unique to clear cell renal cancer (ccRCC). Identify relationships between the prevalence of VHL gene alterations and alteration subtypes with patient and tumor characteristics.