Detection of YMDD mutant using a novel sensitive method in chronic liver disease type B patients before and during lamivudine treatment.

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Abstract

The emergence of lamivudine-resistant hepatitis B virus (HBV) was reported in patients with prolonged lamivudine administration. There was no report of the existence of tyrosine-methionine-aspartate-aspartate (YMDD) mutant in non-lamivudine treated chronic hepatitis B patients. In the present study, we developed a sensitive assay and applied it to the detection of YMDD mutant.

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Journal

Journal ID (iso-abbrev): J. Hepatol.

Title: Journal of hepatology

Publisher: Elsevier BV

ISSN: 0168-8278

ISSN (Print): 0168-8278

Publication date (Electronic): Aug 2002

Volume: 37

Issue: 2

Affiliations

[1 ] Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Japan.

Article

Publisher Item ID: S0168827802001459

DOI: 10.1016/s0168-8278(02)00145-9

PubMed ID: 12127432

SO-VID: d7114a35-ca8a-4a29-b407-0ab7353084ee

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