For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
22
views
38
references
 Top references
cited by
21
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      359
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      A comparative study of the osteogenic performance between the hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface and the SLA surface

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Three-dimensional (3D) printed titanium and its alloys have broad application prospect in the field of biomedical implant materials, although the biological performance of the original surface should be improved. Learning from the development experience of conventional titanium implants, to construct a hierarchical hybrid topological surface is the future direction of efforts. Since the original 3D-printed (3D hereafter) Ti6Al4V surface inherently has micron-scale features, in the present study, we introduced submicron-scale pits on the original surface by acid etching to obtain a hierarchical micro/submicro-textured surface. The characteristic and biological performance of the 3D-printed and acid-etched (3DA hereafter) surface were evaluated in vitro and in vivo, compared with the conventional sandblasted, large-grit, acid-etched (SLA hereafter) surface. Our results suggested the adhesion, proliferation and osteogenic differentiation of bone marrow derived mesenchymal stromal cells (BMSCs), as well as the in vivo osseointegration on 3DA surfaces were significantly improved. However, the overall osteogenic performance of the 3DA surface was not as good as the conventional SLA surface.

          Graphical abstract

          Highlights

          • •

            Hierarchical micro/submicro-textured 3D-printed Ti6Al4V surface was fabricated.

          • •

            Osteogenic performance in vitro and in vivo was enhanced after acid etching.

          • •

            A gap existed between the hierarchical 3D-printed surface and the SLA surface.

          Related collections

          Most cited references38

          • Record: found
          • Abstract: found
          • Article: not found

          Additive manufacturing. Continuous liquid interface production of 3D objects.

          John R Tumbleston, David Shirvanyants, Nikita Ermoshkin … (2015)
          Additive manufacturing processes such as 3D printing use time-consuming, stepwise layer-by-layer approaches to object fabrication. We demonstrate the continuous generation of monolithic polymeric parts up to tens of centimeters in size with feature resolution below 100 micrometers. Continuous liquid interface production is achieved with an oxygen-permeable window below the ultraviolet image projection plane, which creates a "dead zone" (persistent liquid interface) where photopolymerization is inhibited between the window and the polymerizing part. We delineate critical control parameters and show that complex solid parts can be drawn out of the resin at rates of hundreds of millimeters per hour. These print speeds allow parts to be produced in minutes instead of hours.
          Article 0 comments Cited 541 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Mechanical properties and the hierarchical structure of bone.

            J. Rho, L. T. Kuhn-Spearing, P Zioupos (1998)
            Detailed descriptions of the structural features of bone abound in the literature; however, the mechanical properties of bone, in particular those at the micro- and nano-structural level, remain poorly understood. This paper surveys the mechanical data that are available, with an emphasis on the relationship between the complex hierarchical structure of bone and its mechanical properties. Attempts to predict the mechanical properties of bone by applying composite rule of mixtures formulae have been only moderately successful, making it clear that an accurate model should include the molecular interactions or physical mechanisms involved in transfer of load across the bone material subunits. Models of this sort cannot be constructed before more information is available about the interactions between the various organic and inorganic components. Therefore, further investigations of mechanical properties at the 'materials level', in addition to the studies at the 'structural level' are needed to fill the gap in our present knowledge and to achieve a complete understanding of the mechanical properties of bone.
            Article 0 comments Cited 411 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

              Soroosh Derakhshanfar, Rene Mbeleck, Kaige Xu … (2018)
              3D printing, an additive manufacturing based technology for precise 3D construction, is currently widely employed to enhance applicability and function of cell laden scaffolds. Research on novel compatible biomaterials for bioprinting exhibiting fast crosslinking properties is an essential prerequisite toward advancing 3D printing applications in tissue engineering. Printability to improve fabrication process and cell encapsulation are two of the main factors to be considered in development of 3D bioprinting. Other important factors include but are not limited to printing fidelity, stability, crosslinking time, biocompatibility, cell encapsulation and proliferation, shear-thinning properties, and mechanical properties such as mechanical strength and elasticity. In this review, we recite recent promising advances in bioink development as well as bioprinting methods. Also, an effort has been made to include studies with diverse types of crosslinking methods such as photo, chemical and ultraviolet (UV). We also propose the challenges and future outlook of 3D bioprinting application in medical sciences and discuss the high performance bioinks.
              Article 0 comments Cited 321 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Fengshan Chen
                Xudong Wang
                Kaili Lin
                Journal
                Journal ID (nlm-ta): Bioact Mater
                Journal ID (iso-abbrev): Bioact Mater
                Title: Bioactive Materials
                Publisher: KeAi Publishing
                ISSN (Electronic): 2452-199X
                Publication date PMC-release: 09 January 2020
                Publication date Collection: March 2020
                Publication date (Electronic): 09 January 2020
                Volume: 5
                Issue: 1
                Pages: 9-16
                Affiliations
                [a ]Department of Orthodontics, School & Hospital of Stomatology, Tongji University; Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai, 200072, China
                [b ]Department of Oral & Cranio-Maxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, 200011, China
                [c ]School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China
                Author notes
                [∗ ]Corresponding author. lklecnu@ 123456aliyun.com
                [∗∗ ]Corresponding author. 13681746901@ 123456126.com
                [∗∗∗ ]Corresponding author. xudongwang70@ 123456hotmail.com
                [1]

                Co-first authors.

                Article
                Publisher ID: S2452-199X(19)30076-3
                DOI: 10.1016/j.bioactmat.2019.12.008
                PMC ID: 6956677
                PubMed ID: 31956731
                SO-VID: d6e7730e-32de-42f3-b4dc-f5874c20a212
                Copyright © © 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 2 December 2019
                Date revision received : 28 December 2019
                Date accepted : 28 December 2019
                Categories
                Subject: Article

                Keywords: 3d printing,ti6al4v,surface modification,osteogenesis,sla
                Data availability:
                Keywords: 3d printing, ti6al4v, surface modification, osteogenesis, sla

                Comments

                Comment on this article

                scite_

                Similar content359

                See all similar

                Cited by21

                See all cited by

                Most referenced authors391

                See all reference authors